- ►nih.gov JM Zigman, Y Nakano, R Coppari, N … - Journal of Clinical …, 2005 - Am Soc Clin Investig Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHSR; ghrelin
receptor). Since its discovery, accumulating evidence has suggested that ghrelin may play a
role in signaling and reversing states of energy insufficiency. For example, ghrelin levels ... Cited by 141 - Related articles - BL Direct - All 17 versions
DE Cummings - Physiology & behavior, 2006 - Elsevier Ghrelin, an acylated upper gastrointestinal peptide, is the only known orexigenic hormone. Considerable
evidence implicates ghrelin in mealtime hunger and meal initiation. Circulating levels decrease
with feeding and increase before meals, achieving concentrations sufficient to stimulate ... Cited by 118 - Related articles - All 4 versions
JM Zigman, JE Jones, CE Lee, CB Saper, … - Journal of …, 2006 - utsouthwestern.edu ABSTRACT Ghrelin is a hormone that stimulates growth hormone secretion and signals energy
insufficiency via interaction with its receptor, the growth hormone secretagogue receptor
(GHSR). The GHSR is located in both the central nervous system and the periphery. Its ... Cited by 96 - Related articles - View as HTML - BL Direct - All 8 versions
- ►nih.gov DJ Drucker - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The gastrointestinal tract has a crucial role in the control of energy homeostasis through its role
in the digestion, absorption, and assimilation of ingested nutrients. Furthermore, signals from
the gastrointestinal tract are important regulators of gut motility and satiety, both of which ... Cited by 87 - Related articles - BL Direct - All 11 versions
Y Sun, M Asnicar, PK Saha, L Chan, RG Smith - Cell metabolism, 2006 - Elsevier Ghrelin and leptin are suggested to regulate energy homeostasis as mutual antagonists on hypothalamic
neurons that regulate feeding behavior. We employed reverse genetics to investigate the interplay
between ghrelin and leptin. Leptin-deficient mice (ob/ob) are hyperphagic, obese, and ... Cited by 71 - Related articles - All 11 versions
- ►endojournals.org R Granata, F Settanni, L Biancone, L Trovato, R Nano, … - Endocrinology, 2007 - Endocrine Soc Among its pleiotropic actions, ghrelin modulates insulin secretion and glucose metabolism. Herein
we investigated the role of ghrelin in pancreatic ß-cell proliferation and apoptosis induced by
serum starvation or interferon (IFN)- /TNF- , whose synergism is a major cause for ß-cell ... Cited by 40 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org K Dezaki, H Sone, M Koizumi, M Nakata, M Kakei, H … - Diabetes, 2006 - Am Diabetes Assoc The gastric hormone ghrelin and its receptor, growth hormone secretagogue receptor
(GHSR), are expressed in pancreas. Here, we report that ghrelin is released from pancreatic
islets to regulate glucose-induced insulin release. Plasma concentrations of ghrelin, as ... Cited by 42 - Related articles - BL Direct - All 6 versions
JA Gutierrez, PJ Solenberg, DR Perkins, … - Proceedings of the …, 2008 - National Acad Sciences The peptide hormone ghrelin is the only known protein modified with an O-linked octanoyl side
group, which occurs on its third serine residue. This modification is crucial for ghrelin's physiological
effects including regulation of feeding, adiposity, and insulin secretion. Despite the crucial ... Cited by 40 - Related articles - BL Direct - All 7 versions
X Zhu, Y Cao, K Voodg, DF Steiner - Journal of Biological Chemistry, 2006 - ASBMB The orexigenic hormone ghrelin is a 28-amino-acid peptide derived from a 99-amino-acid precursor
and acylated at Ser-3, which was initially isolated from rat stomach. In addition to stimulating
appetite and growth, it also plays various important roles in energy homeostasis and in ... Cited by 37 - Related articles - All 7 versions
RG Smith, H Jiang, Y Sun - Trends in Endocrinology & Metabolism, 2005 - Elsevier The spiropiperidine, MK0677, has been exploited to characterize and expression clone the growth
hormone secretagogue receptor (GHS-R). Cloning of this receptor led to identification of its natural
ligands, ghrelin and adenosine. Targeted disruption of the Ghsr gene demonstrated ... Cited by 35 - Related articles - All 7 versions
