- ►nih.gov RK Gupta, MZ Vatamaniuk, CS Lee, RC … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Mutations in the gene encoding hepatocyte nuclear factor-4α (HNF-4α) result in
maturity-onset diabetes of the young (MODY). To determine the contribution of
HNF-4α to the maintenance of glucose homeostasis by the β cell in vivo, ... Cited by 75 - Related articles - All 7 versions
- ►diabetesjournals.org JC Koster, MA Permutt, CG Nichols - Diabetes, 2005 - Am Diabetes Assoc The ATP-sensitive K + channel (K ATP channel) senses metabolic changes in the
pancreatic β-cell, thereby coupling metabolism to electrical activity and
ultimately to insulin secretion. When K ATP channels open, β-cells ... Cited by 43 - Related articles - BL Direct - All 5 versions
JV Rocheleau, MS Remedi, B Granada, WS … - biology.plosjournals.org The soil nematodes Caenorhabditis briggsae and Caenorhabditis elegans diverged
from a common ancestor roughly 100 million years ago and yet are almost
indistinguishable by eye. They have the same chromosome number and genome ... Cited by 22 - Related articles - Cached - BL Direct - All 13 versions
MS Remedi, JV Rocheleau, A Tong, BL Patton … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis ATP-sensitive K + (K ATP ) channels couple glucose
metabolism to insulin secretion in pancreatic beta cells. In humans,
loss-of-function mutations of beta cell K ATP subunits (SUR1, encoded by ... Cited by 13 - Related articles - BL Direct - All 4 versions
- ►fasebj.org B Malester, XY Tong, I Ghiu, A Kontogeorgis … - The FASEB Journal, 2007 - FASEB K ATP channels are involved in regulating coronary function, but the
contribution of endothelial K ATP channels remains largely uncharacterized. We
generated a transgenic mouse model to specifically target endothelial K ATP ... Cited by 9 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org JC Koster, MS Remedi, R Masia, B Patton, A … - Diabetes, 2006 - Am Diabetes Assoc Glucose metabolism in pancreatic β-cells elevates cytoplasmic [ATP]/[ADP],
causing closure of ATP-sensitive K + channels (K ATP channels), Ca 2+ entry
through voltage-dependent Ca 2+ channels, and insulin release. Decreased ... Cited by 9 - Related articles - BL Direct - All 5 versions
AJ Smith, TK Taneja, J Mankouri, A … - Expert Reviews in Molecular Medicine, 2007 - Cambridge Univ Press ATP-sensitivepotassium(K ATP )channelsplayakeyroleintheregulationofinsulin
secretion by coupling glucose metabolism to the electrical activity of
pancreatic b-cells. To generate an electric signal of suitable magnitude, ... Cited by 4 - Related articles - All 2 versions
MS Remedi, CG Nichols - PLoS Med, 2008 - medicine.plosjournals.org Pancreatic β-cell ATP-sensitive potassium (K ATP ) channels are critical links
between nutrient metabolism and insulin secretion. In humans, reduced or absent
β-cell K ATP channel activity resulting from loss-of-function K ATP ... Cited by 4 - Related articles - Cached - All 8 versions
- ►endojournals.org [PDF] MA Ravier, M Nenquin, T Miki, S Seino, JC … - Endocrinology, 2008 - Endocrine Soc Page 1. 1 Glucose controls cytosolic Ca 2+ and insulin secretion in mouse islets
lacking ATP-sensitive K + channels owing to a knockout of the pore-forming ... Cited by 2 - Related articles
CG Nichols, JC Koster, MS Remedi - Diabetes, Obesity and Metabolism, 2007 - interscience.wiley.com Nutrient oxidation in β cells generates a rise in [ATP]:[ADP] ratio. This
reduces K ATP channel activity, leading to depolarization, activation of
voltage-dependent Ca 2+ channels, Ca 2+ entry and insulin secretion. ... Cited by 2 - Related articles - All 2 versions
