S Bonner-Weir, GC Weir - Nature biotechnology, 2005 - nature.com Two major initiatives are under way to correct the -cell deficit of diabetes:
one would generate -cells ex vivo that are suitable for transplantation, and the
second would stimulate regeneration of -cells in the pancreas. Studies of ... Cited by 172 - Related articles - All 3 versions
- ►physoc.org P Newsholme, EP Haber, SM Hirabara, ELO … - The Journal of Physiology, 2007 - Physiological Soc It is now widely accepted, given the current weight of experimental evidence,
that reactive oxygen species (ROS) contribute to cell and tissue dysfunction and
damage caused by glucolipotoxicity in diabetes. The source of ROS in the ... Cited by 60 - Related articles - BL Direct - All 8 versions
- ►ucla.edu [PDF] JJ MEIER, A BHUSHAN, PC BUTLER - Pediatric research, 2006 - journals.lww.com Both type 1 and type 2 diabetes are characterized by a marked deficit in
beta-cell mass causing insufficient insulin secretion. Beta-cell replacement
strategies may eventually provide a cure for diabetes. Current therapeutic ... Cited by 32 - Related articles - BL Direct - All 7 versions
- ►cell.com ST Gangaram-Panday, MM Faas, P de Vos - Trends in Molecular Medicine, 2007 - Elsevier Many approaches of stem-cell therapy for the treatment of diabetes have been
described. One is the application of stem cells for replacement of nonfunctional
islet cells in the native endogenous pancreas; another one is the use of ... Cited by 30 - Related articles - All 6 versions
DQ Tang, S Lu, YP Sun, E Rodrigues, W Chou … - Laboratory Investigation, 2006 - pathology.ufl.edu Adenovirus-mediated transient expression of the pancreatic duodenal homeobox
transcription factor Pdx1 in mouse liver activates pancreatic endocrine and
exocrine genes, the latter reportedly resulting in severe hepatitis. ... Cited by 27 - Related articles - View as HTML - BL Direct - All 6 versions
- ►pubget.com [PDF] A Fodor, C Harel, L Fodor, M Armoni, P Salmon … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis We examined a clinical model of ex vivo
transdifferentiation of primary adult hepatocytes to insulin- secreting cells
for the treatment of type 1 diabetes. Materials and methods Isolated rat ... Cited by 22 - Related articles - BL Direct - All 5 versions
A Leri, J Kajstura, P Anversa - Physiology (Bethesda, Md.), 2005 - ncbi.nlm.nih.gov 1: Physiology (Bethesda). 2005 Jun;20:162-8. Identity deception: not a crime
for a stem cell. Leri A, Kajstura J, Anversa P. Cardiovascular ... Cited by 18 - Related articles - All 5 versions
- ►mcgill.ca [PDF] I Todorov, K Omori, M Pascual, J Rawson, I … - Pancreas, 2006 - journals.lww.com Skip Navigation Links Home > March 2006 - Volume 32 - Issue 2 > Generation of
Human Islets Through Expansion and Differentia... ... From the Southern
California Islet Cell Resources Center, Department of Diabetes, ... Cited by 18 - Related articles - BL Direct - All 4 versions
- ►nih.gov DA Babu, TG Deering, RG Mirmira - Molecular genetics and metabolism, 2007 - Elsevier Emerging evidence over the past decade indicates a central role for
transcription factors in the embryonic development of pancreatic islets and the
consequent maintenance of normal glucose homeostasis. Pancreatic and ... Cited by 17 - Related articles - All 3 versions
