PE MacDonald, JW Joseph, P Rorsman - Philosophical Transactions of the Royal Society B: …, 2005 - rstb.royalsocietypublishing.org The appropriate secretion of insulin from pancreatic β-cells is critically
important to the maintenance of energy homeostasis. The β-cells must sense and
respond suitably to postprandial increases of blood glucose, and ... Cited by 61 - Related articles - BL Direct - All 13 versions
AC Riggs, E Bernal-Mizrachi, M Ohsugi, J … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 2313–2321 DOI 10.1007/s00125-005-1947-4 ARTICLE
AC Riggs . E. Bernal-Mizrachi . M. Ohsugi . J. Wasson . S. Fatrai . ... Cited by 41 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org EP Kwan, HY Gaisano - Diabetes, 2005 - Am Diabetes Assoc Glucagon-like peptide 1 (GLP-1) has been postulated to potentiate insulin
secretion by cAMP-mediated enhancement of mobilization and priming of secretory
granules, but the precise exocytic events are unknown. We used ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►jbc.org AV Gyulkhandanyan, SC Lee, G Bikopoulos, … - Journal of Biological Chemistry, 2006 - ASBMB In pancreatic -cells Zn 2+ is crucial for insulin biosynthesis and exocytosis.
Despite this, little is known about mechanisms of Zn 2+ transport into -cells or
the regulation and compartmentalization of Zn 2+ within this cell type. ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►endojournals.org BA Spurlin, DC Thurmond - Molecular Endocrinology, 2006 - Endocrine Soc Numerous overexpression studies have recently implicated Syntaxin 4 as an
effector of insulin secretion, although its requirement in insulin granule
exocytosis is unknown. To address this, islets from Syntaxin 4 heterozygous ... Cited by 21 - Related articles - BL Direct - All 4 versions
- ►endojournals.org BJ Marsh, C Soden, C Alarcon, BL Wicksteed … - Molecular Endocrinology, 2007 - Endocrine Soc Endocrine cells are continually regulating the balance between hormone
biosynthesis, secretion, and intracellular degradation to ensure that cellular
hormone stores are maintained at optimal levels. In pancreatic ß-cells, ... Cited by 14 - Related articles - BL Direct - All 3 versions
- ►cell.com DJ Michael, H Cai, W Xiong, J Ouyang, RH … - Trends in Endocrinology & Metabolism, 2006 - Elsevier According to the classical view, peptide hormones are stored in large dense-core
vesicles that release all of their cargo rapidly and completely when they fuse
with and flatten into the plasma membrane. However, recent imaging studies ... Cited by 13 - Related articles - All 4 versions
- ►rupress.org T Rose, S Efendic, M Rupnik - Journal of General Physiology, 2007 - jgp.rupress.org The Goto Kakizaki (GK) rat is a widely used animal model to study defective
glucose-stimulated insulin release in type-2 diabetes (T2D). As in T2D patients,
the expression of several proteins involved in Ca 2+ -dependent exocytosis ... Cited by 10 - Related articles - BL Direct - All 5 versions
- ►jbc.org JL Jewell, W Luo, E Oh, Z Wang, DC … - Journal of Biological Chemistry, 2008 - ASBMB Glucose-induced insulin exocytosis is coupled to associations between F-actin
and SNARE proteins, although the nature and function of these interactions
remains unknown. Toward this end we show here that both Syntaxin 1A and ... Cited by 8 - Related articles - All 5 versions
- ►diabetesjournals.org DJ Michael, W Xiong, X Geng, P Drain, RH … - Diabetes, 2007 - Am Diabetes Assoc In healthy individuals, plasma insulin levels oscillate in both fasting and fed
states. Numerous studies of isolated pancreata and pancreatic islets support the
hypothesis that insulin oscillations arise because the underlying rate of ... Cited by 8 - Related articles - BL Direct - All 5 versions
