RJ Shaw, KA Lamia, D Vasquez, SH Koo, N Bardeesy, … - Science, 2005 - sciencemag.org The Peutz-Jegher syndrome tumor-suppressor gene encodes a protein-threonine kinase,
LKB1, which phosphorylates and activates AMPK [adenosine monophosphate (AMP)–activated
protein kinase]. The deletion of LKB1 in the liver of adult mice resulted in a nearly ... Cited by 300 - Related articles - BL Direct - All 17 versions
- ►ahajournals.org J Kim, Y Wei, JR Sowers - Circulation research, 2008 - Am Heart Assoc Insulin resistance is characteristic of obesity, type 2 diabetes, and components of the cardiometabolic
syndrome, including hypertension and dyslipidemia, that collectively contribute to a substantial
risk for cardiovascular disease. Metabolic actions of insulin in classic insulin target tissues ... Cited by 49 - Related articles - All 6 versions
- ►physiology.org L Bertrand, A Ginion, C Beauloye, AD … - American Journal of …, 2006 - Am Physiological Soc Diabetic hearts are known to be more susceptible to ischemic disease. Biguanides, like
metformin, are known antidiabetic drugs that lower blood glucose concentrations by decreasing
hepatic glucose production and increasing glucose disposal in muscle. Part of these ... Cited by 31 - Related articles - BL Direct - All 3 versions
- ►psychiatryonline.org RR Wu, JP Zhao, XF Guo, YQ He, MS … - American journal of …, 2008 - Am Psychiatric Assoc OBJECTIVE: The purpose of this study was to assess the efficacy of metformin in preventing
olanzapine-induced weight gain. METHOD: Forty patients with schizophrenia were randomly
assigned to treatment for 12 weeks with olanzapine, 15 mg/day, plus metformin, 750 ... Cited by 27 - Related articles - BL Direct - All 6 versions
- ►physiology.org AC Smith, KL Mullen, KA Junkin, J … - American Journal of …, 2007 - Am Physiological Soc Derangements in skeletal muscle fatty acid (FA) metabolism associated with insulin resistance
in obesity appear to involve decreased FA oxidation and increased accumulation of lipids such
as ceramides and diacylglycerol (DAG). We investigated potential lipid-related ... Cited by 25 - Related articles - BL Direct - All 6 versions
- ►endojournals.org ME Cleasby, TA Reinten, GJ Cooney, DE James, … - Molecular …, 2007 - Endocrine Soc The phosphoinositide 3-kinase/Akt pathway is thought to be essential for normal insulin action
and glucose metabolism in skeletal muscle and has been shown to be dysregulated in insulin
resistance. However, the specific roles of and signaling pathways triggered by Akt ... Cited by 16 - Related articles - BL Direct - All 4 versions
L Tosca, P Solnais, P Ferré, F Foufelle, J … - Biology of …, 2006 - Soc Study Reprod Metformin is an anti-diabetic drug commonly used to treat cycle disorders and anovulation in
women with polycystic ovary syndrome. However, the effects and molecular mechanism of metformin
in the ovary are not entirely understood. We investigated the effects of this drug on ... Cited by 12 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org ME Cleasby, JR Davey, TA Reinten, MW Graham, DE … - Diabetes, 2005 - Am Diabetes Assoc Analysis of conventional germ-line or tissue-specific gene manipulation in vivo is potentially
confounded by developmental adaptation of animal physiology. We aimed to adapt the technique
of in vivo electrotransfer (IVE) to alter local gene expression in skeletal muscle of rodents ... Cited by 10 - Related articles - BL Direct - All 5 versions
- ►endojournals.org Z Zhang, X Li, W Lv, Y Yang, H Gao, J Yang, Y … - Molecular …, 2008 - Endocrine Soc Ginsenoside Re (Re), a compound derived from Panax ginseng, shows an antidiabetic
effect. However, the molecular basis of its action remains unknown. We investigated insulin signaling
and the antiinflammatory effect by Re in 3T3-L1 adipocytes and in high-fat diet (HFD) rats ... Cited by 9 - Related articles - BL Direct - All 4 versions
