- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is critical for blood
glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia
to induce hepatic glucose output. The control of glucagon secretion is multifactorial and ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►endojournals.org BE Dunning, JE Gerich - Endocrine reviews, 2007 - Endocrine Soc The hyperglycemic activity of pancreatic extracts was encountered some 80 yr ago during efforts
to optimize methods for the purification of insulin. The hyperglycemic substance was named
"glucagon," and it was subsequently determined that glucagon is a 29-amino acid peptide ... Cited by 32 - Related articles - BL Direct - All 5 versions
- ►physiology.org EM Sinclair, DJ Drucker - Physiology, 2005 - Am Physiological Soc The proglucagon-derived peptides (PGDPs) are encoded by a single mammalian proglucagon
gene. Tissue-specific posttranslational processing mediated by prohormone convertase
(PC) enzymes liberates these peptide hormones in a tissue-specific manner (FIGURE 1 ... Cited by 30 - Related articles - All 4 versions
L Agius - Best Practice & Research Clinical Endocrinology & …, 2007 - Elsevier Type-2 diabetes is associated with impaired glucose clearance by the liver in the postprandial
state, and with elevated glucose production in the post-absorptive state. New targets within the
liver are currently being investigated for development of antihyperglycaemic drugs for ... Cited by 17 - Related articles - All 17 versions
SL Conarello, G Jiang, J Mu, Z Li, J Woods, E Zycband, … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis Under normal physiological conditions, glucagon signalling is important
in glucose homeostasis. Hyperglucagonaemia or altered insulin:glucagon ratio plays a role in
maintaining hyperglycaemia in subjects with type 2 diabetes. It has been reported that ... Cited by 11 - Related articles - BL Direct - All 4 versions
KW Sloop, MD Michael, JS Moyers - Expert Opin. Ther. Targets, 2005 - informahealthcare.com Glucagon is the key counter-regulatory hormone that opposes the action of insulin. In states of
relative hypoglycaemia, glucagon acts to increase blood glucose by stimulating hepatic glycogen
breakdown and gluconeogenesis to achieve euglycaemia. Type 2 diabetes is ... Cited by 12 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org I Quesada, E Tuduri, C Ripoll, A Nadal - Journal of Endocrinology, 2008 - Soc Endocrinology The secretion of glucagon by pancreatic -cells plays a critical role in the regulation of
glycaemia. This hormone counteracts hypoglycaemia and opposes insulin actions by stimulating
hepatic glucose synthesis and mobilization, thereby increasing blood glucose ... Cited by 8 - Related articles - All 3 versions
DM Shen, F Zhang, EJ Brady, MR Candelore, Q … - Bioorganic & Medicinal …, 2005 - Elsevier AM1 computer modeling of compound 1 with the three peripheral substituents truncated for ease
of computation showed conformers A and B to have very similar energies. 12 A quick visual inspection
revealed that a slightly lower energy conformer B was well-suited for the formation of a ... Cited by 6 - Related articles - All 4 versions
- ►aspetjournals.org N Rivera, CA Everett-Grueter, DS Edgerton, T … - Journal of Pharmacology …, 2007 - ASPET Elevated glucagon is associated with fasting hyperglycemia in type 2 diabetes. We assessed
the effects of the glucagon receptor antagonist (2R)-N-[4-({4-(1-cyclohexen-1-yl)[(3,5-dichloroanilino
)carbonyl]anilino}methyl)benzoyl]-2-hydroxy-b-alanine (NNC 25-0926) on hepatic ... Cited by 3 - Related articles - All 5 versions
C Xiao… - Clinical science (London, England: 1979), 2007 - pubmedcentral.nih.gov Pancreatic bi-hormones insulin and glucagon are the Yin and Yang in the regulation of glucose
metabolism and homoeostasis. Insulin is synthesized primarily by pancreatic β-cells and is released
in response to an increase in blood glucose levels (hyperglycaemia). By contrast, ... Cited by 3 - Related articles - BL Direct - All 9 versions
