- ►nih.gov [PDF] RL Craig, WS Chu, SC Elbein - Molecular genetics and metabolism, 2007 - Elsevier Serum retinol binding protein 4 (RBP4) was recently described as a new adipokine
that reduced peripheral and hepatic insulin sensitivity and increased hepatic
gluconeogenesis. The RBP4 gene maps to 10q23-24, near a region linked to ... Cited by 35 - Related articles - All 4 versions
SK Das, SC Elbein - Cellscience, 2006 - pubmedcentral.nih.gov Type 2 Diabetes results from a complex physiologic process that includes the
pancreatic beta cells, peripheral glucose uptake in muscle, the secretion of
multiple cytokines and hormone-like molecules from adipocytes, hepatic ... Cited by 25 - Related articles - All 3 versions
SK Das, SC Elbein - Current Diabetes Reports, 2007 - Springer The unbiased approach of genome-wide linkage analysis has shown evidence for
linkage of type 2 diabetes mel- litus to the chromosome 1q21-25 region in at
least eight independent studies. More than 26 candidate genes have already ... Cited by 14 - Related articles - BL Direct - All 2 versions
MA Karim, X Wang, TC Hale, SC Elbein - BMC Medical Genetics, 2005 - biomedcentral.com We identified 8 variants in the two populations, including a 3 bp insertion in
exon 2 (InsCCG243) in African Americans that resulted in an in-frame proline
insertion in the transactivation domain. No variant was associated with ... Cited by 12 - Related articles - Cached - All 8 versions
- ►diabetesjournals.org SK Das, WS Chu, TC Hale, X Wang, RL Craig, … - Diabetes, 2006 - Am Diabetes Assoc Linkage of type 2 diabetes to chromosome 1q21-q23 is well replicated across
populations. In an initial 50-kb marker map (580 markers) across the linked
region, one of the two strongest associations observed in Utah Caucasians ... Cited by 12 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org M Fu, CM Damcott, M Sabra, TI Pollin, SH Ott, … - Diabetes, 2004 - Am Diabetes Assoc Calsequestrin (CASQ)1 is involved in intracellular storage and release of
calcium, a process that has been shown to mediate glucose transport in muscle.
Its gene, CASQ1, is encoded on chromosome 1q21, a region that has been ... Cited by 12 - Related articles - BL Direct - All 5 versions
MA Karim, RL Craig, X Wang, TC Hale, SC … - Molecular Genetics and Metabolism, 2006 - Elsevier The human forkhead box O1A (FOXO1A) gene on chromosome 13q14.1 is a key
transcription factor in insulin signaling in liver and adipose tissue and plays
a central role in the regulation of key pancreatic β-cell genes including ... Cited by 9 - Related articles - All 3 versions
- ►helsinki.fi [PDF] H Wang, SC Elbein - … IN MOLECULAR BIOLOGY-CLIFTON THEN TOTOWA …, 2007 - Springer Summary Single-nucleotide polymorphisms (SNPs) are common in the human genome,
with more than 11 million SNPs having frequencies greater than 1%. The challenge
is to identify the minority of functional SNPs from the large number of ... Cited by 8 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org WS Chu, SK Das, H Wang, JC Chan, P Deloukas … - Diabetes, 2007 - Am Diabetes Assoc Activating transcription factor 6 (ATF6) is located within the region of linkage
to type 2 diabetes on chromosome 1q21-q23 and is a key activator of the
endoplasmic reticulum stress response. We evaluated 78 single nucleotide ... Cited by 8 - Related articles - BL Direct - All 12 versions
SJ Hasstedt, WS Chu, SK Das, H Wang, SC … - Annals of Human Genetics, 2008 - interscience.wiley.com Type 2 diabetes (T2D) has been linked to chromosome 1q21–24 in multiple
samples, including a Utah family sample. Variants in 13 of the numerous
candidate genes in the 1q region were tested for association with T2D in a ... Cited by 4 - Related articles - BL Direct - All 3 versions
