R Saxena, L Gianniny, NP Burtt, V Lyssenko, C … - Diabetes, 2006 - Am Diabetes Assoc Recently, common noncoding variants in the TCF7L2 gene were strongly associated with increased
risk of type 2 diabetes in samples from Iceland, Denmark, and the US We genotyped 13 single
nucleotide polymorphisms (SNPs) across TCF7L2 in 8,310 individuals in family-based ... Cited by 160 - Related articles - BL Direct - All 4 versions
JL Leahy - Archives of medical research, 2005 - Elsevier The pathological sequence for type 2 diabetes is complex and entails many different elements
that act in concert to cause that disease. This review proposes a sequence of events and how
they interact by a careful analysis of the human and animal model literature. A genetic ... Cited by 102 - Related articles - All 14 versions
V Lyssenko, P Almgren, D Anevski, M Orho- … - PLoS …, 2005 - medicine.plosjournals.org By using a Cox proportional hazard model, common variants in the PPARG (P12A), CAPN10
(SNP43 and 44), KCNJ11 (E23K), UCP2 (−866G>A), and IRS1 (G972R) genes were studied
for their ability to predict T2D in 2,293 individuals participating in the Botnia study in ... Cited by 63 - Related articles - Cached - BL Direct - All 10 versions
- ►diabetesjournals.org W Winckler, RR Graham, PIW de Bakker, M Sun, P … - Diabetes, 2005 - Am Diabetes Assoc Two recent publications reported association of common polymorphisms in the P2 promoter
of hepatocyte nuclear factor 4α (HNF4α) (the MODY1 gene) with risk for type 2 diabetes. We
attempted to reproduce this putative association by genotyping 11 single nucleotide ... Cited by 59 - Related articles - All 8 versions
- ►diabetesjournals.org HN Lyon, JC Florez, T Bersaglieri, R Saxena, W … - Diabetes, 2006 - Am Diabetes Assoc The common missense single nucleotide polymorphism (SNP) K121Q in the ectoenzyme nucleotide
pyrophosphate phosphodiesterase (ENPP1) gene has recently been associated with type 2
diabetes in Italian, US, and South-Asian populations. A three-SNP haplotype, including ... Cited by 48 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org W Winckler, NP Burtt, J Holmkvist, C Cervin, PIW de … - Diabetes, 2005 - Am Diabetes Assoc It is currently unclear how often genes that are mutated to cause rare, early-onset monogenic
forms of disease also harbor common variants that contribute to the more typical polygenic form
of each disease. The gene for MODY3 diabetes, HNF1α, lies in a region that has shown ... Cited by 46 - Related articles - BL Direct - All 6 versions
- ►cell.com ACP Thirone, C Huang, A Klip - Trends in Endocrinology & Metabolism, 2006 - Elsevier In type 2-diabetes and impaired glucose tolerance, the muscle, fat and liver become resistant
to insulin, and recent developments place dysregulation of insulin receptor substrate (IRS) expression
and activation at the center of such defects. IRS1 and IRS2 are the major insulin receptor ... Cited by 42 - Related articles - All 7 versions
- ►nih.gov R Saxena, PIW de Bakker, K Singer, V Mootha, N … - The American Journal of …, 2006 - Elsevier Many lines of evidence implicate mitochondria in phenotypic variation: (a) rare mutations in mitochondrial
proteins cause metabolic, neurological, and muscular disorders; (b) alterations in oxidative phosphorylation
are characteristic of type 2 diabetes, Parkinson disease, Huntington disease, and other ... Cited by 40 - Related articles - BL Direct - All 10 versions
KF Manly - Immunogenetics, 2005 - Springer Abstract Many statistical associations between a disease and alleles of specific genes have proven
to be irrepro- ducible. In part, this irreproducibility can be attributed to a lack of replication before
publication and the fact that, until recently, the relationship between statistical significance ... Cited by 37 - Related articles - BL Direct - All 4 versions
H Parikh, E Carlsson, WA Chutkow, LE … - PLoS …, 2007 - medicine.plosjournals.org We combined human insulin/glucose clamp physiological studies with genome-wide expression
profiling to identify thioredoxin interacting protein (TXNIP) as a gene whose expression is powerfully
suppressed by insulin yet stimulated by glucose. In healthy individuals, its expression ... Cited by 35 - Related articles - Cached - All 15 versions
