V Lyssenko, P Almgren, D Anevski, M Orho- … - PLoS Medicine, 2005 - medicine.plosjournals.org By using a Cox proportional hazard model, common variants in the PPARG (P12A),
CAPN10 (SNP43 and 44), KCNJ11 (E23K), UCP2 (−866G>A), and IRS1 (G972R) genes
were studied for their ability to predict T2D in 2,293 individuals ... Cited by 63 - Related articles - Cached - BL Direct - All 10 versions
JC Florez, M Sjögren, N Burtt, M Orho- … - Diabetes, 2004 - Am Diabetes Assoc The insulin receptor substrate (IRS)-1 is an important component of the insulin
signal transduction cascade. Several reports suggest that a Gly→Arg change in
codon 972 is associated with type 2 diabetes and related traits, and a ... Cited by 49 - Related articles - BL Direct - All 4 versions
- ►nih.gov MI McCarthy, E Zeggini - Current Diabetes Reports, 2006 - Springer Introduction The growing prevalence of type 2 diabetes and obesity in societies
worldwide is widely recognized as among the greatest threats to global health in
the coming century [1]. Nevertheless, we remain far from a comprehensive ... Cited by 31 - Related articles - BL Direct - All 8 versions
SK Das, SC Elbein - Cellscience, 2006 - pubmedcentral.nih.gov Type 2 Diabetes results from a complex physiologic process that includes the
pancreatic beta cells, peripheral glucose uptake in muscle, the secretion of
multiple cytokines and hormone-like molecules from adipocytes, hepatic ... Cited by 25 - Related articles - All 3 versions
JC Florez, M Sjögren, CM Agapakis, NP Burtt, … - Diabetologia, 2007 - Springer Page 1. ARTICLE Association testing of common variants in the insulin receptor
substrate-1 gene (IRS1) with type 2 diabetes JC Florez ... Cited by 3 - Related articles - BL Direct - All 4 versions
S Prudente, D Scarpelli, M Chandalia, YY Zhang … - Journal of Clinical Endocrinology & Metabolism, 2009 - Endocrine Soc Context: The prevalence of type 2 diabetes (T2D), particularly among young
adults, has been rising steadily during the past 2 decades. T2D, especially in
its early-onset subtype, is under genetic control. TRIB3 inhibits insulin- ... Cited by 3 - Related articles - All 4 versions
G Sesti, ML Hribal - Current Pharmacogenomics, 2006 - ingentaconnect.com Abstract: Type 2 diabetes is a complex and heterogeneous metabolic condition
that has reached epidemic proportions, affecting more than 150 million
individuals worldwide. Maintenance of near-normal glucose control in ... Cited by 2 - Related articles - BL Direct
J Rung, S Cauchi, A Albrechtsen, L Shen, G … - Nature Genetics, 2009 - nature.com Genome-wide association studies have identified common variants that only
partially explain the genetic risk for type 2 diabetes (T2D). Using genome-wide
association data from 1,376 French individuals, we identified 16,360 SNPs ... Cited by 1 - Related articles - All 3 versions
