J Wang, T Yoshida, F Nakaki, H Hiai, T … - Proceedings of the …, 2005 - National Acad Sciences Mice deficient in programmed cell death 1 (PD-1, Pdcd1), an immunoinhibitory receptor belonging
to the CD28/cytotoxic T lymphocyte-associated antigen-4 family, spontaneously develop
lupus-like autoimmune disease and autoimmune dilated cardiomyopathy on C57BL/6 ... Cited by 63 - Related articles - BL Direct - All 9 versions
- ►harvard.edu [PDF] LS Wicker, J Clark, HI Fraser, VES Garner, A … - Journal of Autoimmunity, 2005 - Elsevier The identification of causative genes for the autoimmune disease type 1 diabetes (T1D) in humans
and candidate genes in the NOD mouse has made significant progress in recent years. In addition
to sharing structural aspects of the MHC class II molecules that confer susceptibility or ... Cited by 42 - Related articles - All 6 versions
- ►nih.gov JC Roach, K Deutsch, S Li, AF Siegel, LM Bekris, … - The American Journal of …, 2006 - Elsevier We mapped the genetic influences for type 1 diabetes (T1D), using 2,360 single-nucleotide polymorphism
(SNP) markers in the 4.4-Mb human major histocompatibility complex (MHC) locus and the adjacent
493 kb centromeric to the MHC, initially in a survey of 363 Swedish T1D cases and ... Cited by 22 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org UC Rogner, F Lepault, MC Gagnerault, D Vallois, J … - Diabetes, 2006 - Am Diabetes Assoc The genetic locus Idd6 confers susceptibility to the spontaneous development of type 1 diabetes
in the NOD mouse. Our studies on disease resistance of the congenic mouse strain NOD.C3H
6.VIII showed that Idd6 influences T-cell activities in the peripheral immune system and ... Cited by 10 - Related articles - BL Direct - All 7 versions
- ►oxfordjournals.org MS Hung, P Avner, UC Rogner - Human Molecular Genetics, 2006 - Oxford Univ Press The Idd6 murine type 1 diabetes locus has been shown to control diabetes by regulating the
protective activity of the peripheral immune system, as demonstrated by diabetes transfer assays
using splenocytes. The analysis of three novel subcongenic (NOD.C3H nonobese. C3H) ... Cited by 8 - Related articles - BL Direct - All 6 versions
- ►jimmunol.org Y Inoue, T Kaifu, A Sugahara-Tobinai, A … - The Journal of …, 2007 - Am Assoc Immnol Type 1 diabetes mellitus (T1D) in humans is an organ-specific autoimmune disease in which
pancreatic islet cells are ruptured by autoreactive T cells. NOD mice, the most commonly used
animal model of T1D, show early infiltration of leukocytes in the islets (insulitis), resulting ... Cited by 7 - Related articles - All 5 versions
- ►nih.gov Z Su, S Tsaih, J Szatkiewicz, Y Shen, B Paigen - Science's STKE, 2008 - stke.sciencemag.org Abstract: To identify the genes controlling plasma concentrations of triglycerides (TGs),
FFAs, and glucose, we carried out a quantitative trait loci (QTL) analysis of the closely related
mouse strains New Zealand Black (NZB/B1NJ) and New Zealand White (NZW/LacJ), ... Cited by 5 - Related articles - All 8 versions
AA Chentoufi, NR Binder, N Berka, T … - Scandinavian …, 2008 - interscience.wiley.com Type 1 diabetes (T1D) is an autoimmune disease resulting from the destruction of insulin-producing
pancreatic β cells by autoreactive T cells. The polygenic trait for T1D risk implicates many genes
that have an impact on fundamental immunological processes such as central and ... Cited by 3 - Related articles - BL Direct - All 4 versions
C Huber, A Martensson, GM Bokoch, D Nemazee, … - Journal of Biological …, 2008 - ASBMB Members of the Fgd (faciogenital dysplasia) gene family encode a group of critical guanine nucleotide
exchange factors (GEFs), which, by specifically activating Cdc42, control cytoskeleton-dependent
membrane rearrangements. In its first characterization, we find that FGD2 is expressed in ... Cited by 2 - Related articles - All 3 versions
Z Su, SW Tsaih, J Szatkiewicz, Y Shen, B Paigen - The Journal of Lipid …, 2008 - ASBMB Page 1. Candidate genes for plasma triglyceride, free fatty acid, and glucose revealed
from an intercross between inbred mouse strains NZB/B1NJ x NZW/LacJ Zhiguang Su,
Shirng-Wern Tsaih, Jin Szatkiewicz, Yuan Shen, Beverly Paigen ... Cited by 3 - Related articles - All 2 versions
