OP Kristiansen, T Mandrup-Poulsen - Diabetes, 2005 - Am Diabetes Assoc Inflammatory mechanisms play a key role in the pathogenesis of type 1 diabetes. Individuals
who progress to type 2 diabetes display features of low-grade inflammation years in advance
of disease onset. This low-grade inflammation has been proposed to be involved in the ... Cited by 72 - Related articles - BL Direct - All 5 versions
H Yoshie, T Kobayashi, H Tai, JC Galicia - Periodontology 2000, 2007 - pt.wkhealth.com A detailed knowledge of the dynamic between the host immune responses and oral bacteria
is essential to understand clearly the pathogenesis of periodontal disease. Periodontopathic
bacteria initiate and repeatedly attack the host, stimulating an immune response, but the ... Cited by 36 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org M Vaxillaire, J Veslot, C Dina, C Proença, S Cauchi, G … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— The GCK (Glucokinase) −30A allele was associated with increased type 2 diabetes
risk at the end of the follow-up study (adjusted OR 1.34 [95% CI 1.07–1.69]) under an additive
model, as supported in independent French diabetic case subjects (OR 1.22, P = 0.007), ... Cited by 34 - Related articles - BL Direct - All 4 versions
- ►endojournals.org H Wang, Z Zhang, W Chu, T Hale, JJ Cooper, … - Journal of Clinical …, 2005 - Endocrine Soc IL-6 levels and polymorphisms have been implicated in type 2 diabetes mellitus (T2DM) and
insulin resistance. The IL-6 receptor (IL-6R) comprises two subunits, IL-6R and gp130, of which
IL-6R confers specificity to IL-6 action and is located in a region of replicated linkage to ... Cited by 28 - Related articles - All 5 versions
M Hoene, C Weigert - Obesity Reviews, 2008 - interscience.wiley.com Interleukin-6 (IL-6) is a central player in the regulation of inflammation, haematopoiesis, immune
response and host defense mechanisms. During the last decade, an accumulating amount of
data suggested a pivotal role for IL-6 in metabolic processes, thus fortifying the picture of ... Cited by 17 - Related articles - BL Direct - All 4 versions
E Esteve, G Villuendas, J Mallolas, J … - CLINICAL …, 2006 - interscience.wiley.com Objective Low-grade inflammation has been related to obesity, insulin resistance and the metabolic
syndrome. The Asp358Ala variant and the CA-repeat polymorphism in the interleukin-6 receptor
(IL-6R) gene have been reported to be associated with obesity in Pima Indians and ... Cited by 16 - Related articles - BL Direct - All 4 versions
AJP Smith, SE Humphries - Cytokine and Growth Factor Reviews, 2009 - Elsevier Cytokines, signaling proteins produced by a variety of cell types, are essential for the development
and functioning of both innate and adaptive immune response. Cytokine gene expression is
tightly regulated, and aberrant expression from environmental and genetic polymorphism ... Cited by 16 - Related articles - All 21 versions
SK Das, SC Elbein - Current Diabetes Reports, 2007 - Springer The unbiased approach of genome-wide linkage analysis has shown evidence for linkage of
type 2 diabetes mel- litus to the chromosome 1q21-25 region in at least eight independent
studies. More than 26 candidate genes have already been evaluated, but to date none ... Cited by 14 - Related articles - BL Direct - All 2 versions
N Angelopoulos, A Goula, G Tolis - Metabolism, 2005 - Elsevier Obesity is today one of the commonest of life-threatening diseases in developed countries and
generally results from an imbalance between energy intake and energy expenditure. Although
there is increasing evidence for a genetic basis of obesity in some clinical syndromes, this ... Cited by 11 - Related articles - All 11 versions
EJ Brunner, M Kivimäki, DR Witte, DA Lawlor, G … - PLoS …, 2008 - medicine.plosjournals.org We genotyped three tagging SNPs (CRP + 2302G > A; CRP + 1444T > C; CRP + 4899T > G)
in the CRP gene and measured serum CRP in 5,274 men and women at mean ages 49 and
61 y (Whitehall II Study). Homeostasis model assessment-insulin resistance (HOMA-IR) ... Cited by 10 - Related articles - Cached - All 9 versions
