- ►hematologylibrary.org Y Liang, T Huang, C Zhang, I Todorov, M … - …, 2005 - bloodjournal.hematologylibrary.org Prevention of autoimmune diabetes and induction of islet transplantation tolerance in nonobese
diabetic (NOD) mice can be reached by induction of mixed chimerism via bone marrow transplantation
(BMT), but this procedure requires total body irradiation (TBI) conditioning of the ... Cited by 34 - Related articles - All 6 versions
- ►vpro.nl [PDF] EH Leiter, M Von Herrath - Diabetologia, 2004 - Springer The contrarians have to agree with their opponents that animal models in general, and rodent
models of Type 1 diabetes in particular, are imperfect reflections of human disease [1]. This is
the inevitable conse- quence of an evolutionary separation of over 65 mil- lion years. ... Cited by 21 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org B Zhang, Y Lu, M Campbell-Thompson, T Spencer, C … - Diabetes, 2007 - Am Diabetes Assoc Type 1 diabetes is an autoimmune disease resulting from destruction of the insulin-producing
islet β-cells (1). Multiple lines of evidence indicate that antigen-presenting cells (APCs), especially
dendritic cells, are pathologically active in orchestrating the process of insulitis (2). APCs ... Cited by 20 - Related articles - BL Direct - All 4 versions
J Neu, M Douglas-Escobar, M Lopez - Nutrition in Clinical Practice, 2007 - ncp.sagepub.com During the course of mammalian evolution, there has been a close relationship between microbes
residing in the gastrointestinal (GI) tract and the mammalian host. Although the host provides
the microbes with a warm environment and nutrients, they, in turn, undergo various ... Cited by 16 - Related articles - BL Direct - All 3 versions
W Chen, JA Bluestone, KC Herold - International reviews of …, 2005 - informahealthcare.com Autoreactive T cells that escape negative selection in the thymus do not normally cause productive
immune responses to self-antigens because of a number of regulatory mechanisms. Studies
with anti-CD3 monoclonal antibodies (mAbs) have suggested that immune regulatory ... Cited by 9 - Related articles - BL Direct - All 5 versions
SA Sarkar, R Wong, SI Hackl, O Moua, RG Gill, A … - Diabetes, 2007 - Am Diabetes Assoc Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial, rate-limiting step of tryptophan (Trp)
catabolism along the kynurenine (KYN) pathway, and its induction in cells of the immune system
in response to cytokines has been implicated in the regulation of antigen presentation ... Cited by 6 - Related articles - BL Direct - All 5 versions
B Zhang, Y Lu, M Campbell-Thompson, T Spencer, C … - Diabetes, 2007 - Am Diabetes Assoc -Cell apoptosis appears to represent a key event in the pathogenesis of type 1 diabetes. Previous
studies have demonstrated that administration of the serine proteinase inhibitor 1-antitrypsin
(AAT) prevents type 1 diabetes development in NOD mice and prolongs islet allograft ... Cited by 5 - Related articles - All 2 versions
S Cernea, KC Herold - Nature Reviews Endocrinology, 2006 - nature.com Animal models and human studies have provided strong evidence that the immune response
that causes type 1A diabetes is initiated against a limited array of antigens but acquires breadth
and depth until -cell mass has been critically compromised. Two recent trials confirmed ... Cited by 4 - Related articles - BL Direct - All 3 versions
