KN Frayn - Proceedings of the Nutrition Society, 2007 - Cambridge Univ Press Obesity is a risk factor for the development of type 2 diabetes and CVD. Is adipose tissue the
culprit in the relationship between obesity and metabolic disease? It is certainly possible to argue
that adipose tissue function is disturbed in obesity in such a way that adverse ... Cited by 47 - Related articles - All 5 versions
A Hammarstedt, CX Andersson, V Rotter Sopasakis … - … , Leukotrienes & Essential …, 2005 - Elsevier Insulin resistance is frequently accompanied by obesity and both obesity and type 2 diabetes
are associated with a mild chronic inflammation. Elevated levels of various cytokines, such as
TNF-α and IL-6, are typically found in the adipose tissue in these conditions. It has been ... Cited by 48 - Related articles - All 6 versions
- ►fasebj.org AM Hennige, N Stefan, K Kapp, R Lehmann, C Weigert, … - The FASEB Journal, 2006 - FASEB Insulin resistance in skeletal muscle is found in obesity and type 2 diabetes. A mechanism for
impaired insulin signaling in peripheral tissues is the inhibition of insulin action through serine
phosphorylation of insulin receptor substrate (Irs) proteins that abolish the coupling of Irs ... Cited by 36 - Related articles - BL Direct - All 5 versions
RB Ceddia - International Journal of Obesity, 2005 - nature.com In recent years, the adipose tissue has emerged as an important endocrine organ. It is now recognized
that besides storing energy the adipocytes also secrete several bioactive peptides, collectively
called adipocytokines. Among these adipocytokines, leptin, the product of the ob gene, ... Cited by 35 - Related articles - BL Direct - All 3 versions
- ►physiology.org PM Thule, AG Campbell, DJ Kleinhenz, … - American Journal of …, 2006 - Am Physiological Soc Hepatic insulin gene therapy (HIGT) ameliorates hyperglycemia in diabetic rodents, suggesting
that similar approaches may eventually provide a means to improve treatment of diabetes
mellitus. However, whether the metabolic and hormonal changes produced by HIGT ... Cited by 22 - Related articles - BL Direct - All 5 versions
- ►leptiprorx.com [PDF] Y Benomar, S Wetzler, C Larue-Achagiotis, J … - Molecular and cellular …, 2005 - Elsevier Leptin resistance contributes to the pathogenesis of common obesity related metabolic
diseases, including insulin resistance. However, the relationship between leptin and insulin resistance
is not clearly established. Here, we show that induced hyperleptinemia by leptin infusion ... Cited by 20 - Related articles - All 13 versions
SD Vangipuram, M Yu, J Tian, KL Stanhope, M … - International Journal of …, 2006 - nature.com Ad-36 suppressed the expression of leptin mRNA in 3T3-L1 cells by approximately 58 and
52% on days 3 and 5 post-infection, respectively. Leptin release normalized to cellular lipid content
was 51% lower (P<0.002) in the Ad-36 infected 3T3-L1 cells. Lipid accumulation was ... Cited by 19 - Related articles - BL Direct - All 4 versions
- ►physiology.org P Perez-Matute, A Marti, JA Martinez, MP … - American Journal of …, 2005 - Am Physiological Soc Eicosapentaenoic acid (EPA), one of the n-3 polyunsaturated fatty acids, has been shown to
stimulate leptin mRNA expression and secretion in 3T3-L1 cells. However, other studies have
reported inhibitory effects of EPA on leptin expression and secretion in vivo and in vitro. ... Cited by 16 - Related articles - All 4 versions
- ►endocrinology-journals.org F Escriva, ML Gavete, Y Fermin, C Perez, N … - Journal of …, 2007 - Soc Endocrinology Insulin resistance develops with ageing in humans and rodents. Here, we have studied the evolution
of insulin sensitivity with ageing trying to discriminate the role of adiposity from that of ageing
in this process. We performed oral glucose tolerance tests and determined overall and ... Cited by 18 - Related articles - BL Direct - All 4 versions
