- ►shouxi.net GS Eisenbarth, PA Gottlieb - The New England journal of medicine, 2004 - nejm.org Disease is determined by a subgroup of T cells that recognize one or more peptides of the target
organ. These peptides are bound in the groove of HLA molecules and are presented to the
T-cell receptor (TCR) of T lymphocytes. B lymphocytes stimulated by T cells produce ... Cited by 192 - Related articles - BL Direct - All 16 versions
- ►nih.gov P Achenbach, K Koczwara, A Knopff, H … - Journal of Clinical …, 2004 - Am Soc Clin Investig Children at risk for type 1 diabetes can develop early insulin autoantibodies (IAAs). Many, but
not all, of these children subsequently develop multiple islet autoantibodies and diabetes. To
determine whether disease progression is reflected by autoantibody maturity, IAA affinity ... Cited by 66 - Related articles - BL Direct - All 10 versions
- ►ecmaj.com KM Gillespie - Canadian Medical Association Journal, 2006 - ecmaj.com Type 1 diabetes results from the autoimmune destruction of insulin-producing ß cells in the
pancreas. Genetic and, as yet undefined, environmental factors act together to precipitate the
disease. The excess mortality associated with the complications of type 1 diabetes and ... Cited by 61 - Related articles - BL Direct - All 13 versions
- ►angrylapdog.com SS Harris - Journal of Nutrition, 2005 - jn.nutrition.org.p.angrylapdog.com Limited data from human observational studies suggest that early supplementation with 10
µg/d (400 IU/d) or less of vitamin D may not reduce the risk for type 1 diabetes but that doses
of 50 µg/d (2000 IU/d) and higher may have a strong protective effect. Current US ... Cited by 53 - Related articles - All 7 versions
- ►diabetesjournals.org C Pihoker, LK Gilliam, CS Hampe, Å Lernmark - Diabetes, 2005 - Am Diabetes Assoc Islet cell autoantibodies are strongly associated with the development of type 1 diabetes. The
appearance of autoantibodies to one or several of the autoantigens—GAD65, IA-2, or
insulin—signals an autoimmune pathogenesis of β-cell killing. A β-cell attack may be best ... Cited by 53 - Related articles - BL Direct - All 6 versions
R Gianani, GS Eisenbarth - Immunological reviews, 2005 - interscience.wiley.com Summary: Type 1A diabetes is a chronic autoimmune disease usually preceded by a long prodrome
during which autoantibodies to islet autoantigens are present. These antibodies are directed
to a variety of antigens, but the best characterized are glutamic acid decarboxylase-65, ... Cited by 42 - Related articles - All 4 versions
- ►diabetesjournals.org P Achenbach, E Bonifacio, K Koczwara, AG Ziegler - Diabetes, 2005 - Am Diabetes Assoc The natural history of autoimmune type 1 diabetes in children is associated with the appearance
of islet autoantibodies early in life, which is influenced by genetic and environmental factors.
Once islet autoantibodies have developed, the progression to diabetes in ... Cited by 37 - Related articles - BL Direct - All 9 versions
M Schlosser, JP Banga, AM Madec, KA Binder, M … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Progression to type 1 diabetes is associated with intramolecular epitope
spreading to dis- ease-specific antibody epitopes located in the middle re- gion of glutamic acid
decarboxylase 65 (GAD65). Methods: The relationship between intramolecular epitope ... Cited by 33 - Related articles - All 3 versions
CH Wasserfall, MA Atkinson - Autoimmunity Reviews, 2006 - Elsevier Type 1 diabetes results from the autoimmune destruction of the insulin producing pancreatic
β-cells. For years, the notion that T-lymphocytes played a crucial role in the disorder's formation
was considered such sound dogma, that interest in B-lymphocytes and autoantibodies as ... Cited by 31 - Related articles - All 2 versions
MA Atkinson - Diabetes, 2005 - Am Diabetes Assoc Thirty years ago, a convergence of investigational ob- servations lead to the now widely accepted
notion that type 1 diabetes results from an autoimmune destruction of insulin-producing -cells
in subjects genetically pre- disposed to the disease. Improvements in understand- ing of ... Cited by 28 - Related articles - All 3 versions
