R Chiarle, WJ Simmons, H Cai, G Dhall, A … - Nature medicine, 2005 - nature.com 1 Department of Pathology and NYU Cancer Institute, New York University School
of Medicine, 550 First Avenue, New York, New York 10016, USA. ... 2 Center for
Experimental Research and Medical Studies (CERMS) and Department of ... Cited by 94 - Related articles - BL Direct - All 8 versions
BK Gunawan, ZX Liu, D Han, N Hanawa, WA … - Gastroenterology, 2006 - Elsevier Background & Aims: In searching for effects of acetaminophen (APAP) on
hepatocytes downstream of its metabolism that may participate in hepatotoxicity,
we examined the role of stress kinases. Methods: Mouse hepatocytes and ... Cited by 67 - Related articles - All 19 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is
critical for blood glucose homeostasis. It is the major counterpart to insulin
and is released during hypoglycemia to induce hepatic glucose output. The ... Cited by 60 - Related articles - BL Direct - All 4 versions
DJ Drucker - Nature Clinical Practice Endocrinology and Metabolism, 2005 - glucagon.com INTRODUCTION Before the cDNAs and genes encoding pro glucagon were cloned,
pancreatic glucagon was the prin- cipal proglucagon-derived peptide (PGDP) with
well-characterized biologic actions. However, antisera directed against ... Cited by 59 - Related articles - View as HTML - BL Direct - All 6 versions
- ►nih.gov KW Sloop, JXC Cao, AM Siesky, HY Zhang, DM … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig Uncontrolled hepatic glucose production contributes significantly to
hyperglycemia in patients with type 2 diabetes. Hyperglucagonemia is implicated
in the etiology of this condition; however, effective therapies to block ... Cited by 46 - Related articles - BL Direct - All 6 versions
- ►endojournals.org BE Dunning, JE Gerich - Endocrine reviews, 2007 - Endocrine Soc The hyperglycemic activity of pancreatic extracts was encountered some 80 yr ago
during efforts to optimize methods for the purification of insulin. The
hyperglycemic substance was named "glucagon," and it was subsequently ... Cited by 32 - Related articles - BL Direct - All 5 versions
- ►shouxi.net LM Watts, VP Manchem, TA Leedom, AL Rivard … - Diabetes, 2005 - Am Diabetes Assoc Glucocorticoids (GCs) increase hepatic gluconeogenesis and play an important
role in the regulation of hepatic glucose output. Whereas systemic GC inhibition
can alleviate hyperglycemia in rodents and humans, it results in adrenal ... Cited by 29 - Related articles - All 7 versions
- ►physiology.org EM Sinclair, DJ Drucker - Physiology, 2005 - Am Physiological Soc The proglucagon-derived peptides (PGDPs) are encoded by a single mammalian
proglucagon gene. Tissue-specific posttranslational processing mediated by
prohormone convertase (PC) enzymes liberates these peptide hormones in a ... Cited by 29 - Related articles - All 4 versions
JL Estall, DJ Drucker - Current pharmaceutical design, 2006 - ingentaconnect.com Abstract: Glucagon and the glucagon-like peptides are derived from a common
proglucagon precursor, and regulate en- ergy homeostasis through interaction
with a family of distinct G protein coupled receptors. Three ... Cited by 26 - Related articles - BL Direct - All 5 versions
- ►171.66.122.45 MP Keller, YJ Choi, P Wang, D Belt Davis, ME … - Genome Research, 2008 - 171.66.122.45 Insulin resistance is necessary but not sufficient for the development of type 2
diabetes. Diabetes results when pancreatic beta-cells fail to compensate for
insulin resistance by increasing insulin production through an expansion of ... Cited by 27 - Related articles - BL Direct - All 15 versions
