- ►endojournals.org AM Efanov, DG Barrett, MB Brenner, SL Briggs, A … - Endocrinology, 2005 - Endocrine Soc The glucose-sensing enzyme glucokinase (GK) plays a key role in glucose metabolism. We report
here the effects of a novel glucokinase activator, LY2121260. The activator enhanced GK activity
via binding to the allosteric site located in the hinge region of the enzyme. LY2121260 ... Cited by 56 - Related articles - BL Direct - All 5 versions
- ►alfediam.org [PDF] C Postic, R Dentin, J Girard - Diabetes and Metabolism, 2004 - Elsevier The liver plays a unique role in controlling carbohydrate metabolism by maintaining glucose
concentrations in a normal range over both short and long periods of times. In type 2
diabetes, alterations in hepatic glucose metabolism are observed, ie increased post- ... Cited by 47 - Related articles - All 4 versions
B Guigas, L Bertrand, N Taleux, M Foretz, N … - Diabetes, 2006 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) controls glucose uptake and glycolysis in muscle. Little
is known about its role in liver glucose uptake, which is controlled by glucokinase. We report
here that 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR), metformin, ... Cited by 45 - Related articles - BL Direct - All 6 versions
AL Gloyn, S Odili, D Zelent, C Buettger, HAJ … - Journal of Biological …, 2005 - ASBMB Glucokinase (GCK) serves as the pancreatic glucose sensor. Heterozygous inactivating GCK
mutations cause hyperglycemia, whereas activating mutations cause hypoglycemia. We studied
the GCK V62M mutation identified in two families and co-segregating with hyperglycemia ... Cited by 31 - Related articles - All 7 versions
- ►diabetesjournals.org VA Payne, C Arden, C Wu, AJ Lange, L Agius - Diabetes, 2005 - Am Diabetes Assoc Hepatic glucokinase is regulated by a 68-kDa regulatory protein (GKRP) that is both an inhibitor
and nuclear receptor for glucokinase. We tested the role of 6-phosphofructo-2-kinase/fructose
-2,6-bisphosphatase (PFK2) in regulating glucokinase compartmentation in hepatocytes. ... Cited by 29 - Related articles - All 5 versions
M Futamura, H Hosaka, A Kadotani, H Shimazaki, K … - Journal of Biological …, 2006 - ASBMB Glucokinase (GK) plays a key role in the control of blood glucose homeostasis. We identified
a small molecule GK activator, compound A, that increased the glucose affinity and maximal
velocity (V max ) of GK. Compound A augmented insulin secretion from isolated rat islets ... Cited by 25 - Related articles - All 7 versions
FM Matschinsky - Current Diabetes Reports, 2005 - Springer Catalytic Function and Structure of GK Glucokinase or hexokinase IV is one of four
glucose-phospho- rylating isoenzymes in mammalian tissues, which has very distinct structural
and catalytic characteristics [1]. A word about nomenclature is needed: GK is not specific ... Cited by 25 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org JV Sagen, S Odili, L Bjørkhaug, D Zelent, C Buettger, J … - Diabetes, 2006 - Am Diabetes Assoc Glucokinase functions as a glucose sensor in pancreatic β-cells and regulates hepatic glucose
metabolism. A total of 83 probands were referred for a diagnostic screening of mutations in the
glucokinase (GCK) gene. We found 11 different mutations (V62A, G72R, L146R, A208T, ... Cited by 20 - Related articles - BL Direct - All 5 versions
- ►unc.edu [PDF] VV Heredia, J Thomson, D Nettleton, S Sun - Biochemistry, 2006 - pubs.acs.org The transient kinetics of glucose binding to glucokinase (GK) was studied using stopped-flow
fluorescence spectrophotometry to investigate the underlying mechanism of positive cooperativity
of monomeric GK with glucose. Glucose binding to GK was shown to display biphasic ... Cited by 19 - Related articles - All 5 versions
GJ Coope, AM Atkinson, C Allott, D … - British journal of …, 2006 - pubmedcentral.nih.gov Four GKAs (at 1 to 30 mg kg −1 ), with different in vitro enzyme potencies, dose-dependently
improved oral glucose tolerance in HFFZ rats (10–40% decrease glucose area under the curve
(AUC) from vehicle control). The extent of glucose lowering, or the pharmacodynamic ... Cited by 18 - Related articles - BL Direct - All 4 versions
