- ►diabetesjournals.org R Wang, X Liu, ST Hentges, AA Dunn-Meynell, BE … - Diabetes, 2004 - Am Diabetes Assoc Glucosensing neurons in the hypothalamic arcuate nucleus (ARC) were studied using electrophysiological
and immunocytochemical techniques in neonatal male Sprague-Dawley rats. We identified
glucose-excited and -inhibited neurons, which increase and decrease, respectively, their ... Cited by 106 - Related articles - BL Direct - All 5 versions
D Porte, DG Baskin, MW Schwartz - Diabetes, 2005 - Am Diabetes Assoc Insulin and its signaling systems are implicated in both central and peripheral mechanisms governing
the ingestion, distribution, metabolism, and storage of nutrients in organisms ranging from worms
to humans. Input from the environment regarding the availability and type of nutrients is ... Cited by 77 - Related articles - All 8 versions
K Pierre, L Pellerin - Journal of neurochemistry, 2005 - interscience.wiley.com Monocarboxylate transporters (MCTs) are proton-linked membrane carriers involved in the transport
of monocarboxylates such as lactate, pyruvate, as well as ketone bodies. They belong to a larger
family of transporters composed of 14 members in mammals based on sequence ... Cited by 78 - Related articles - All 3 versions
- ►nih.gov L Plum, BF Belgardt, JC Brüning - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Insulin has pleiotropic biological effects in virtually all tissues. However, the relevance of insulin
signaling in peripheral tissues has been studied far more extensively than its role in the
brain. An evolving body of evidence indicates that in the brain, insulin is involved in ... Cited by 76 - Related articles - BL Direct - All 11 versions
- ►korea.ac.kr [PDF] LE Parton, CP Ye, R Coppari, PJ Enriori, B Choi, CY … - Nature, 2007 - nature.com A subset of neurons in the brain, known as 'glucose-excited' neurons, depolarize and increase
their firing rate in response to increases in extracellular glucose. Similar to insulin secretion by
pancreatic -cells 1 , glucose excitation of neurons is driven by ATP-mediated closure of ... Cited by 69 - Related articles - BL Direct - All 5 versions
- ►endojournals.org K Lee, B Li, X Xi, Y Suh, RJ Martin - Endocrinology, 2005 - Endocrine Soc Nutrient sensing in the hypothalamus is tightly related to food intake regulation. However, the
mechanisms by which the nutrient-sensing cells of the brain translate this signal of energy need
into feeding behavior via regulation of neuropeptide expression are not known. To ... Cited by 64 - Related articles - All 5 versions
BM King - Physiology & behavior, 2006 - Elsevier Early researchers found that lesions of the ventromedial hypothalamus (VMH) resulted in hyperphagia
and obesity in a variety of species including humans, which led them to designate the VMH as
the brain's “satiety center.” Many researchers later dismissed a role for the VMH in ... Cited by 64 - Related articles - All 5 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is critical for blood
glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia
to induce hepatic glucose output. The control of glucagon secretion is multifactorial and ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org L Kang, AA Dunn-Meynell, VH Routh, LD Gaspers, Y … - Diabetes, 2006 - Am Diabetes Assoc To test the hypothesis that glucokinase is a critical regulator of neuronal glucosensing, glucokinase
activity was increased, using a glucokinase activator drug, or decreased, using RNA interference
combined with calcium imaging in freshly dissociated ventromedial hypothalamic nucleus ... Cited by 49 - Related articles - BL Direct - All 7 versions
- ►angrylapdog.com BE Levin - … Transactions of the Royal Society B: …, 2006 - rstb.royalsocietypublishing.org.p. … Epidemiological studies in humans suggest that maternal undernutrition, obesity and diabetes
during gestation and lactation can all produce obesity in offspring. Animal models have allowed
us to investigate the independent consequences of altering the pre- versus post-natal ... Cited by 42 - Related articles - BL Direct - All 10 versions
