F Xia, X Gao, E Kwan, PPL Lam, L Chan, K … - Journal of Biological Chemistry, 2004 - ASBMB In pancreatic -cells, the predominant voltage-gated Ca 2+ channel (Ca V 1.2) and
K + channel (K V 2.1) are directly coupled to SNARE (soluble
N-ethylmaleimide-sensitive factor attachment protein (SNAP) receptor) ... Cited by 63 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org J Herrington, YP Zhou, RM Bugianesi, PM … - Diabetes, 2006 - Am Diabetes Assoc Delayed-rectifier K + currents (I DR ) in pancreatic β-cells are thought to
contribute to action potential repolarization and thereby modulate insulin
secretion. The voltage-gated K + channel, K V 2.1, is expressed in ... Cited by 27 - Related articles - BL Direct - All 6 versions
P Proks, JD Lippiat - Current pharmaceutical design, 2006 - ingentaconnect.com Abstract: Type-2, or non-insulin-dependent diabetes mellitus is a serious
disease that is now widespread throughout Western society. Glucose intolerance,
or failure of glucose to stimulate insulin secretion, is a primary factor ... Cited by 19 - Related articles - BL Direct - All 4 versions
K Dezaki, M Kakei, T Yada - Diabetes, 2007 - Am Diabetes Assoc Ghrelin reportedly serves as a physiological regulator of insulin release. This
study aimed to explore signaling mechanisms for insulinostatic ghrelin action in
islet β-cells, with special attention to heterotrimeric GTP-binding ... Cited by 17 - Related articles - BL Direct - All 3 versions
- ►physiology.org H Vacher, DP Mohapatra, JS Trimmer - Physiological Reviews, 2008 - Am Physiological Soc The intrinsic electrical properties and the synaptic input-output relationships
of neurons are governed by the action of voltage-dependent ion channels. The
localization of specific populations of ion channels with distinct ... Cited by 15 - Related articles - All 2 versions
M Braun, R Ramracheya, M Bengtsson, Q … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Human β-cells express two types of voltage-gated K + currents that
flow through delayed rectifying (K V 2.1/2.2) and large-conductance Ca 2+
-activated K + (BK) channels. Blockade of BK channels (using iberiotoxin) ... Cited by 14 - Related articles - All 5 versions
- ►cjb.net D Singer-Lahat, A Sheinin, D Chikvashvili, S … - Science's STKE, 2007 - stke.sciencemag.org Abstract: Kv channels inhibit release indirectly by hyperpolarizing membrane
potential, but the significance of Kv channel interaction with the secretory
apparatus is not known. The Kv2.1 channel is commonly expressed in the soma ... Cited by 13 - Related articles - All 9 versions
- ►physiology.org NM Doliba, W Qin, MZ Vatamaniuk, CW … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Neural and endocrine factors (ie, Ach and GLP-1) restore defective
glucose-stimulated insulin release in pancreatic islets lacking sulfonylurea
type 1 receptors (SUR1 –/– ) (Doliba NM, Qin W, Vatamaniuk MZ, Li C, ... Cited by 12 - Related articles - BL Direct - All 4 versions
- ►physiology.org NA Tamarina, A Kuznetsov, LE Fridlyand, LH … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc The delayed-rectifier (voltage-activated) K + conductance (K V ) in pancreatic
islet -cells has been proposed to regulate plasma membrane repolarization during
responses to glucose, thereby determining bursting and Ca 2+ oscillations. ... Cited by 11 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org L Yan, J Herrington, E Goldberg, PM Dulski, … - Molecular pharmacology, 2005 - ASPET Voltage-gated potassium (Kv) channels regulate many physiological functions and
represent important therapeutic targets in the treatment of several clinical
disorders. Although some of these channels have been well-characterized, ... Cited by 11 - Related articles - All 6 versions
