S Bonner-Weir, GC Weir - Nature biotechnology, 2005 - nature.com Two major initiatives are under way to correct the -cell deficit of diabetes:
one would generate -cells ex vivo that are suitable for transplantation, and the
second would stimulate regeneration of -cells in the pancreas. Studies of ... Cited by 172 - Related articles - All 3 versions
- ►alphamedpress.org Y Shi, L Hou, F Tang, W Jiang, P Wang, M … - Stem Cells, 2005 - AlphaMed Press Experimental induction of embryonic stem cells (ESCs) to become pancreatic ß
cells can potentially provide ample resource for cell transplantation therapy of
type I diabetes mellitus. Most of the previously reported induction ... Cited by 94 - Related articles - All 6 versions
MP Sanderson, SN Erickson, PJ Gough, KJ … - Journal of Biological Chemistry, 2005 - ASBMB Betacellulin belongs to the family of epidermal growth factor-like growth
factors that are expressed as transmembrane precursors and undergo proteolytic
ectodomain shedding to release a soluble mature growth factor. In this ... Cited by 43 - Related articles - All 5 versions
S Werner, C Alzheimer - Cytokine and Growth Factor Reviews, 2006 - Elsevier Activins are transforming growth factor β superfamily members, which were
originally identified as inducers of follicle-stimulating hormone release from
the pituitary. In recent years, however, additional functions of activins ... Cited by 44 - Related articles - All 15 versions
SUN Yu, C Li, HOU Xin-guo, HOU Wei-kai, D … - Chinese medical journal, 2007 - cmj.org Bckground Stem cells, which have the ability to differentiate into
insulin-producing cells (IPCs), would provide a potentially unlimited source of
islet cells for transplantation and alleviate the major limitations of ... Cited by 25 - Related articles - Cached - BL Direct - All 8 versions
HS Jun, JW Yoon - Current gene therapy, 2005 - ingentaconnect.com Abstract: Type 1 diabetes results from insulin deficiency caused by autoimmune
destruction of insulin-producing pancre- atic β cells. Islet transplantation,
β cell regeneration, and insulin gene therapy have been explored in an ... Cited by 20 - Related articles - All 5 versions
PPM Rood, R Bottino, AN Balamurugan, Y … - Pharmaceutical research, 2006 - Springer Received August 30, 2005; accepted October 13, 2005 Abstract. Type 1 diabetes
(T1D) is an autoimmune disease, the clinical onset of which most frequently
presents in children and adolescents who are genetically predisposed. T1D ... Cited by 19 - Related articles - BL Direct - All 4 versions
- ►jhc.org E Bertelli, M Bendayan - Journal of Histochemistry and Cytochemistry, 2005 - Histochemical Soc TRADITIONAL HISTOLOGICAL DESCRIPTIONS of the pancreas divide the exocrine and
the endocrine pancreas into two separate entities, as if they were two distinct
glands. This view is now considered obsolete. Scientists, in fact, have ... Cited by 15 - Related articles - BL Direct - All 5 versions
- ►daegu.ac.kr [PDF] S Yamada, I Kojima - Journal of Hepato-Biliary-Pancreatic Surgery, 2005 - Springer Abstract Diabetes mellitus is a metabolic disorder that affects millions of
people. The number of patients suffering from diabetes continues to increase all
over the world. Both type 1 and type 2 diabetes result from an inadequate ... Cited by 15 - Related articles - All 4 versions
- ►diabetesjournals.org K Silver, M Tolea, J Wang, TI Pollin, F Yao, BD … - Diabetes, 2005 - Am Diabetes Assoc In vitro and in vivo studies suggest a role for betacellulin in islet neogenesis
and regeneration. Since abnormalities in β-cell function play a role in the
development of type 2 diabetes, a mutation in the betacellulin gene could ... Cited by 14 - Related articles - All 5 versions
