- ►uc.pt [PDF] AP Rolo, CM Palmeira - Toxicology and applied pharmacology, 2006 - Elsevier Hyperglycemia resulting from uncontrolled glucose regulation is widely
recognized as the causal link between diabetes and diabetic complications. Four
major molecular mechanisms have been implicated in hyperglycemia-induced ... Cited by 119 - Related articles - All 7 versions
- ►shouxi.net JD MacLellan, MF Gerrits, A Gowing, PJS … - Diabetes, 2005 - Am Diabetes Assoc Decreased uncoupling protein (UCP)3 is associated with insulin resistance in
muscle of pre-diabetic and diabetic individuals, but the function of UCP3
remains unclear. Our goal was to elucidate mechanisms underlying the ... Cited by 79 - Related articles - BL Direct - All 9 versions
TC Esteves, MD Brand - BBA-Bioenergetics, 2005 - Elsevier The mitochondrial uncoupling proteins UCP2 and UCP3 may be important in
attenuating mitochondrial production of reactive oxygen species, in insulin
signalling (UCP2), and perhaps in thermogenesis and other processes. To ... Cited by 59 - Related articles - All 4 versions
KU Lee, IK Lee, J Han, DK Song, YM Kim, HS … - Circulation research, 2005 - Am Heart Assoc Abstract—Increased oxidative stress in vascular cells plays a key role in the
development of endothelial dysfunction and atherosclerosis. Uncoupling protein 2
(UCP2) is an important regulator of intracellular reactive oxygen species ... Cited by 54 - Related articles - All 12 versions
DM Niedowicz, DL Daleke - Cell biochemistry and biophysics, 2005 - Springer The morbidity and mortality associated with diabetes is the result of the myriad
complications related to the disease. One of the most explored hypotheses to
explain the onset of complications is a hyperglycemia-induced increase in ... Cited by 52 - Related articles - BL Direct - All 6 versions
LE Fridlyand, LH Philipson - Diabetes Obesity and Metabolism, 2006 - interscience.wiley.com The early stages of type 2 diabetes mellitus are characterized by the
development of insulin resistance (IRe) in muscle cells and adipocytes with the
concomitant loss of β-cell compensation. We have extensively reviewed the ... Cited by 45 - Related articles - BL Direct - All 4 versions
- ►endojournals.org AM Vincent, L Perrone, KA Sullivan, C Backus … - Endocrinology, 2007 - Endocrine Soc The receptor for advanced glycation end products (RAGE) may promote diabetic
vascular and renal disease through the activation of intracellular signaling
pathways that promote oxidative stress. Oxidative stress is a mediator of ... Cited by 39 - Related articles - BL Direct - All 6 versions
DA Allen, MM Yaqoob, SM Harwood - The Journal of Nutritional Biochemistry, 2005 - Elsevier Cellular responses to high glucose are numerous and varied but ultimately result
in functional changes and, often, cell death. High glucose induces oxidative and
nitrosative stress in many cell types causing the generation of species ... Cited by 40 - Related articles - All 9 versions
- ►jbc.org WS da-Silva, A Gomez-Puyou, MT de Gomez- … - Journal of Biological Chemistry, 2004 - ASBMB Brain hexokinase is associated with the outer membrane of mitochondria, and its
activity has been implicated in the regulation of ATP synthesis and apoptosis.
Reactive oxygen species (ROS) are by-products of the electron transport ... Cited by 37 - Related articles - BL Direct - All 3 versions
D Liu, SL Chan, NC de Souza-Pinto, JR … - Neuromolecular Medicine, 2006 - Springer 1 Laboratory of Neurosciences; 2 Laboratory of Molecular Gerontology; 3 Research
Resources Branch; ... 4 Laboratory of Experimental Gerontology, National
Institute on Aging Intramural Research Program, Baltimore, MD; 5 Department ... Cited by 36 - Related articles - BL Direct - All 2 versions
