- ►diabetesjournals.org M Brownlee - Diabetes, 2005 - Am Diabetes Assoc It's a great honor to join the exceptional club of Banting Award winners, many of whom were
my role models and mentors. In addition, giving the Banting Lecture also has a very personal
meaning to me, because without Frederick Banting, I would have died from type 1 ... Cited by 669 - Related articles - All 4 versions
- ►jbc.org Y Gorin, K Block, J Hernandez, B Bhandari, B … - Journal of Biological …, 2005 - ASBMB Renal hypertrophy and extracellular matrix accumulation are early features of diabetic
nephropathy. We investigated the role of the NAD(P)H oxidase Nox4 in generation of reactive
oxygen species (ROS), hypertrophy, and fibronectin expression in a rat model of type 1 ... Cited by 93 - Related articles - BL Direct - All 5 versions
L Cai, J Wang, Y Li, X Sun, L Wang, Z Zhou, YJ Kang - Diabetes, 2005 - Am Diabetes Assoc The mechanisms of metallothionein prevention of diabetic cardiomyopathy are largely
unknown. The present study was performed to test whether inhibition of nitrosative damage is
involved in metallothionein prevention of diabetic cardiomyopathy. Cardiac-specific ... Cited by 61 - Related articles - All 5 versions
DM Niedowicz, DL Daleke - Cell biochemistry and biophysics, 2005 - Springer The morbidity and mortality associated with diabetes is the result of the myriad complications
related to the disease. One of the most explored hypotheses to explain the onset of complications
is a hyperglycemia-induced increase in oxidative stress. Reactive oxygen species (ROS) ... Cited by 53 - Related articles - BL Direct - All 6 versions
S Menini, L Amadio, G Oddi, C Ricci, C Pesce, F … - Diabetes, 2006 - Am Diabetes Assoc Hyperglycemia plays a central role in diabetic nephropathy, as shown by its prevention or retardation
by strict metabolic control (1,2). The injurious effect of hyperglycemia has been attributed to various
biochemical consequences of intracellular metabolism of excess glucose, including the ... Cited by 47 - Related articles - BL Direct - All 6 versions
RA Kowluru, V Kowluru, Y Xiong, YS Ho - Free Radical Biology and Medicine, 2006 - Elsevier The retina experiences mitochondrial dysfunction in diabetes, superoxide levels are
elevated, and mitochondrial superoxide dismutase (MnSOD) activity is decreased. Inhibition
of superoxide accumulation in diabetes prevents mitochondrial dysfunction, apoptosis of ... Cited by 40 - Related articles - All 5 versions
S Xu, B Jiang, KA Maitland, H Bayat, J Gu, JL Nadler, S … - Diabetes, 2006 - Am Diabetes Assoc Arachidonic acid metabolites, some of which may activate thromboxane A 2 receptors (TPr) and
contribute to the development of diabetes complications, including nephropathy, are elevated
in diabetes. This study determined the effect of blocking TPr with S18886 or inhibiting ... Cited by 38 - Related articles - BL Direct - All 7 versions
- ►nih.gov VR Drel, P Pacher, MJ Stevens, IG Obrosova - Free Radical Biology and …, 2006 - Elsevier Both increased aldose reductase (AR) activity and oxidative/nitrosative stress have been implicated
in the pathogenesis of diabetic nephropathy, but the relation between the two factors remains
a subject of debate. This study evaluated the effects of AR inhibition on nitrosative stress ... Cited by 34 - Related articles - All 6 versions
- ►asnjournals.org S Prabhakar, J Starnes, S Shi, B Lonis, R … - Journal of the American …, 2007 - Am Soc Nephrol The pathogenesis of diabetic nephropathy remains far from clear, partly due to the lack of a suitable
animal model that mimics human renal disease in type 2 diabetes. In this study, the natural history
of renal manifestations in ZSF 1 rats, a recently developed rodent model of type 2 ... Cited by 32 - Related articles - All 4 versions
- ►ebmonline.org YS Kanwar, J Wada, L Sun, P Xie, EI Wallner, S Chen … - Experimental Biology and …, 2008 - SEBM Diabetic nephropathy is characterized by excessive amassing of extracellular matrix (ECM) with
thickening of glomerular and tubular basement membranes and increased amount of mesangial
matrix, which ultimately progress to glomerulosclerosis and tubulo-interstitial fibrosis. In ... Cited by 27 - Related articles - BL Direct - All 2 versions
