NE Zachara, GW Hart - BBA-Molecular and Cell Biology of Lipids, 2006 - Elsevier An increasing body of evidence points to a central regulatory role for glucose in mediating cellular
processes and expands the role of glucose well beyond its traditional role(s) in energy
metabolism. Recently, it has been recognized that one downstream effector produced ... Cited by 79 - Related articles - All 4 versions
DM Niedowicz, DL Daleke - Cell biochemistry and biophysics, 2005 - Springer The morbidity and mortality associated with diabetes is the result of the myriad complications
related to the disease. One of the most explored hypotheses to explain the onset of complications
is a hyperglycemia-induced increase in oxidative stress. Reactive oxygen species (ROS) ... Cited by 53 - Related articles - BL Direct - All 6 versions
JH Jang, YJ Surh - Free Radical Biology and Medicine, 2005 - Elsevier Inflammatory cell death as well as oxidative stress has been implicated in some neurodegenerative
disorders such as Alzheimer's disease (AD). Expression of cyclooxygenase-2 (COX-2) and production
of prostaglandins have been frequently elevated in AD. In this study, we have ... Cited by 36 - Related articles - All 5 versions
YJ Kang, UR Mbonye, CJ DeLong, M Wada, WL … - Progress in Lipid …, 2007 - Elsevier Cyclooxygenases-1 and -2 (COX-1 and -2) catalyze the committed step in prostaglandin
formation. Each isozyme subserves different biological functions. This is, at least in part, a consequence
of differences in patterns of COX-1 and COX-2 expression. COX-1 is induced during ... Cited by 27 - Related articles - All 2 versions
- ►diabetesjournals.org S Li, MA Reddy, Q Cai, L Meng, H Yuan, L Lanting, R … - Diabetes, 2006 - Am Diabetes Assoc Diabetes is associated with enhanced inflammatory responses and cardiovascular complications
such as atherosclerosis. However, it is unclear whether similar responses are present in cells
derived from experimental animal models of diabetes. We examined our hypothesis that ... Cited by 29 - Related articles - BL Direct - All 6 versions
A Giulietti, E van Etten, L Overbergh, K Stoffels, R … - Diabetes research and …, 2007 - Elsevier The exact factors contributing to the pathogenesis of type 2 diabetes remain elusive. Lately, it
was suggested that inflammation and activation of the innate immune system could be linked
to type 2 diabetes pathogenesis and also to the development of common diabetic ... Cited by 22 - Related articles - All 22 versions
- ►endojournals.org EC Kaizer, CL Glaser, D Chaussabel, J … - Journal of Clinical …, 2007 - Endocrine Soc Results: Microarray analysis identified 282 genes differing in expression between newly diagnosed
T1D patients and controls at a false discovery rate of 0.05. Changes in expression of IL1B, early
growth response gene 3, and prostaglandin-endoperoxide synthase 2 resolved within 4 ... Cited by 18 - Related articles - BL Direct - All 3 versions
- ►jbc.org MR Heitmeier, CB Kelly, NJ Ensor, KA Gibson, KG … - Journal of Biological …, 2004 - ASBMB Type I diabetes mellitus is an autoimmune disease characterized by the selective destruction
of the insulin-secreting -cell found in pancreatic islets of Langerhans. Cytokines such as
interleukin-1 (IL-1), interferon- (IFN- ), and tumor necrosis factor- (TNF- ) mediate -cell ... Cited by 17 - Related articles - All 4 versions
ZG Xu, SL Li, L Lanting, YS Kim, N Shanmugam, MA … - Kidney international, 2006 - nature.com The 12/15-lipoxygenase (12/15-LO) and cyclooxygenase-2 (COX-2) pathways of arachidonate
metabolism have been implicated in the pathogenesis of diabetic nephropathy (DN). In this
study, we evaluated whether there is an interplay between 12/15-LO and COX-2 ... Cited by 13 - Related articles - BL Direct - All 3 versions
N Shanmugam, IT Todorov, I Nair, K Omori, MA Reddy, … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: The cyclooxygenase-2 (PTGS2, previously known as COX2) enzyme
and its products, such as prostaglandin E 2 (PGE 2 ), have been implicated in the pathogenesis
of several inflammatory diseases including islet dysfunction under diabetic conditions. In ... Cited by 13 - Related articles - BL Direct - All 3 versions
