- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in
the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise
occurs within the context of β cell compensation for insulin resistance, ... Cited by 199 - Related articles - BL Direct - All 7 versions
JD MacLellan, MF Gerrits, A Gowing, PJS … - Diabetes, 2005 - Am Diabetes Assoc Decreased uncoupling protein (UCP)3 is associated with insulin resistance in
muscle of pre-diabetic and diabetic individuals, but the function of UCP3
remains unclear. Our goal was to elucidate mechanisms underlying the ... Cited by 79 - Related articles - BL Direct - All 9 versions
- ►nih.gov L Abu-Elheiga, MM Matzuk, P Kordari, WK Oh, … - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences Acetyl-CoA carboxylases (ACC1 and ACC2) catalyze the carboxylation of acetyl-CoA
to form malonyl-CoA, an intermediate metabolite that plays a pivotal role in the
regulation of fatty acid metabolism. We previously reported that ACC2 null ... Cited by 63 - Related articles - BL Direct - All 8 versions
- ►physiology.org MJ MacDonald, LA Fahien, LJ Brown, NM … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc The importance of mitochondrial biosynthesis in stimulus secretion coupling in
the insulin-producing -cell probably equals that of ATP production. In
glucose-induced insulin secretion, the rate of pyruvate carboxylation is ... Cited by 60 - Related articles - All 4 versions
- ►diabetesjournals.org CJ Nolan, MSR Madiraju, V Delghingaro- … - Diabetes, 2006 - Am Diabetes Assoc Fatty acids (FAs) and other lipid molecules are important for many cellular
functions, including vesicle exocytosis. For the pancreatic β-cell, while the
presence of some FAs is essential for glucose-stimulated insulin secretion, ... Cited by 55 - Related articles - BL Direct - All 5 versions
Z Hu, Y Dai, M Prentki, S Chohnan, MD Lane - Journal of Biological Chemistry, 2005 - ASBMB The cellular level of malonyl-CoA, an intermediate in fatty acid biosynthesis,
depends on its rate of synthesis catalyzed by acetyl-CoA carboxylase relative to
its rate of utilization and degradation catalyzed by fatty acid synthase ... Cited by 50 - Related articles - BL Direct - All 6 versions
MG Latour, T Alquier, E Oseid, C Tremblay, TL … - Diabetes, 2007 - Am Diabetes Assoc Long-chain fatty acids amplify insulin secretion from the pancreatic β-cell.
The G-protein–coupled receptor GPR40 is specifically expressed in β-cells and
is activated by fatty acids; however, its role in acute regulation of ... Cited by 47 - Related articles - BL Direct - All 6 versions
S Gremlich, C Nolan, R Roduit, R Burcelin, … - Endocrinology, 2005 - Endocrine Soc The cellular response to fasting and starvation in tissues such as heart,
skeletal muscle, and liver requires peroxisome proliferator-activated receptor-
(PPAR )-dependent up-regulation of energy metabolism toward fatty acid ... Cited by 47 - Related articles - All 5 versions
- ►endojournals.org K Ravnskjaer, M Boergesen, B Rubi, JK Larsen … - Endocrinology, 2005 - Endocrine Soc Fatty acids (FAs) are known to be important regulators of insulin secretion from
pancreatic ß-cells. FA-coenzyme A esters have been shown to directly stimulate
the secretion process, whereas long-term exposure of ß-cells to FAs ... Cited by 45 - Related articles - BL Direct - All 2 versions
