G Keller - Genes & development, 2005 - genesdev.cshlp.org The discovery of mouse embryonic stem (ES) cells >20 years ago represented a major advance
in biology and experimental medicine, as it enabled the routine manipulation of the mouse
genome. Along with the capacity to induce genetic modifications, ES cells provided the ... Cited by 373 - Related articles - BL Direct - All 12 versions
S Bonner-Weir, GC Weir - Nature biotechnology, 2005 - nature.com Two major initiatives are under way to correct the -cell deficit of diabetes: one would generate
-cells ex vivo that are suitable for transplantation, and the second would stimulate regeneration
of -cells in the pancreas. Studies of ex vivo expansion suggest that -cells have a potential ... Cited by 175 - Related articles - All 3 versions
- ►amjpathol.org T Fujikawa, SH Oh, L Pi, HM Hatch, T Shupe, BE … - American Journal of …, 2005 - ASIP Embryonic stem (ES) cells have been proposed to be a powerful tool in the study of pancreatic
disease, as well as a potential source for cell replacement therapy in the treatment of
diabetes. However, data demonstrating the feasibility of using pancreatic islet-like cells ... Cited by 139 - Related articles - All 8 versions
- ►alphamedpress.org J Jiang, M Au, K Lu, A Eshpeter, G Korbutt, G Fisk, AS … - Stem Cells, 2007 - AlphaMed Press Recent success in pancreatic islet transplantation has energized the field to discover an alternative
source of stem cells with differentiation potential to ß cells. Generation of
glucose-responsive, insulin-producing ß cells from self-renewing, pluripotent human ... Cited by 96 - Related articles - BL Direct - All 7 versions
- ►neiltheise.com [PDF] MA Hussain, ND Theise - The Lancet, 2004 - Elsevier Curative therapy for diabetes mellitus mainly implies replacement of functional insulin-producing
pancreatic β cells, with pancreas or islet-cell transplants. However, shortage of donor organs
spurs research into alternative means of generating β cells from islet expansion, ... Cited by 83 - Related articles - All 8 versions
- ►diabetesjournals.org GKC Brolén, N Heins, J Edsbagge, H Semb - Diabetes, 2005 - Am Diabetes Assoc The recent success in restoring normoglycemia in type 1 diabetes by islet cell transplantation
indicates that cell replacement therapy of this severe disease is achievable. However, the severe
lack of donor islets has increased the demand for alternative sources of β-cells, such as ... Cited by 81 - Related articles - BL Direct - All 6 versions
- ►alphamedpress.org CG Liew, JS Draper, J Walsh, H Moore, PW Andrews - Stem Cells, 2007 - AlphaMed Press Plasmid vectors remain a valuable yet capricious tool for the genetic manipulation of human
embryonic stem (hES) cells. We have compared the efficacy of four promoters to mediate transient
and stable transfection in hES and human embryonal carcinoma cell lines with the ... Cited by 74 - Related articles - BL Direct - All 14 versions
P Blyszczuk, C Asbrand, A Rozzo, G Kania, L St-Onge, … - Int J Dev Biol, 2004 - ijdb.ehu.es ABSTRACT We present a new strategy for the differentiation of embryonic stem (ES) cells into
insulin-producing cells via a multi-step process without selection and induction of nestin-positive
cells. During ES cell differentiation, transcript levels of genes characteristic of early and ... Cited by 66 - Related articles - View as HTML - All 6 versions
N Ende, R Chen, AS Reddi - Biochemical and Biophysical Research …, 2004 - Elsevier Several studies have shown that transplantation of embryonic stem cells into diabetic animals
either improved or normalized blood glucose levels. In this study, we examined the dose-dependent
effect of early (prediabetic stage) intravenous administration of human umbilical cord ... Cited by 60 - Related articles - All 5 versions
- ►calvin.edu [PDF] Y Zhao, H Wang, T Mazzone - Experimental cell research, 2006 - Elsevier We identified stem cells from the umbilical cord blood, designated cord blood–stem cells
(CB–SC). CB–SC displayed important embryonic stem (ES) cell characteristics including expression
of ES-cell-specific molecular markers including transcription factors OCT-4 and Nanog, ... Cited by 60 - Related articles - All 7 versions
