- ►physiology.org S Seino, T Shibasaki - Physiological reviews, 2005 - Am Physiological Soc Stimulus-secretion coupling is an essential process in secretory cells in which regulated exocytosis
occurs, including neuronal, neuroendocrine, endocrine, and exocrine cells. While an increase
in intracellular Ca 2+ concentration ([Ca 2+ ] i ) is the principal signal, other intracellular ... Cited by 146 - Related articles - BL Direct - All 4 versions
I Franklin, J Gromada, A Gjinovci, S Theander, CB … - Diabetes, 2005 - Am Diabetes Assoc Glucagon, secreted from islet α-cells, mobilizes liver glucose. During hyperglycemia, glucagon
secretion is inhibited by paracrine factors from other islet cells, but in type 1 and type 2 diabetic
patients, this suppression is lost. We investigated the effects of β-cell secretory products ... Cited by 74 - Related articles - All 4 versions
- ►diabetesjournals.org MA Ravier, GA Rutter - Diabetes, 2005 - Am Diabetes Assoc The mechanisms by which hypoglycemia stimulates glucagon release are still poorly
understood. In particular, the relative importance of direct metabolic coupling versus paracrine
regulation by β-cell secretory products is unresolved. Here, we compare the responses to ... Cited by 66 - Related articles - All 5 versions
- ►nih.gov X Jing, DQ Li, CS Olofsson, A Salehi, VV … - Journal of Clinical …, 2005 - Am Soc Clin Investig Concerted activation of different voltage-gated Ca 2+ channel isoforms may determine the kinetics
of insulin release from pancreatic islets. Here we have elucidated the role of R-type Ca V 2.3
channels in that process. A 20% reduction in glucose-evoked insulin secretion was ... Cited by 64 - Related articles - All 9 versions
- ►diabetesjournals.org J Gromada, X Ma, M Høy, K Bokvist, A Salehi, PO … - Diabetes, 2004 - Am Diabetes Assoc Patch-clamp recordings and glucagon release measurements were combined to determine the
role of plasma membrane ATP-sensitive K + channels (K ATP channels) in the control of glucagon
secretion from mouse pancreatic α-cells. In wild-type mouse islets, glucose produced a ... Cited by 59 - Related articles - BL Direct - All 5 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is critical for blood
glucose homeostasis. It is the major counterpart to insulin and is released during hypoglycemia
to induce hepatic glucose output. The control of glucagon secretion is multifactorial and ... Cited by 61 - Related articles - BL Direct - All 4 versions
CG Ostenson, H Gaisano, L Sheu, A Tibell, T Bartfai - Diabetes, 2006 - Am Diabetes Assoc Exocytosis of insulin is dependent on the soluble N-ethylmaleimide attachment protein receptor
(SNARE) complex proteins in the B-cells. We assessed insulin release as well as gene and protein
expression of SNARE complex protein in isolated pancreatic islets of type 2 diabetic ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►endojournals.org HL Olsen, S Theander, K Bokvist, K Buschard, CB … - Endocrinology, 2005 - Endocrine Soc In isolated rat pancreatic -cells, glucose, arginine, and the sulfonylurea tolbutamide stimulated
glucagon release. The effect of glucose was abolished by the K ATP -channel opener diazoxide
as well as by mannoheptulose and azide, inhibitors of glycolysis and mitochondrial ... Cited by 43 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org PE MacDonald, S Obermüller, J Vikman, J … - Diabetes, 2005 - Am Diabetes Assoc We have applied cell-attached capacitance measurements to investigate whether synaptic-like
microvesicles (SLMVs) undergo regulated exocytosis in insulinoma and primary pancreatic
β-cells. SLMV and large dense-core vesicle (LDCV) exocytosis was increased 1.6- and ... Cited by 33 - Related articles - All 5 versions
- ►jbc.org J Diao, Z Asghar, CB Chan, MB Wheeler - Journal of Biological Chemistry, 2005 - ASBMB The insulin receptor (IR) and its signaling appear to be essential for insulin secretion from pancreatic
-cells. However, much less is known about the role of the IR in -cells. To assess the role of the
IR in glucagon and insulin secretion, we engineered adeno-viruses for high efficiency ... Cited by 32 - Related articles - BL Direct - All 6 versions
