DG Hardie, D Carling - European Journal of Biochemistry, 1997 - journal.shouxi.net The LKB1AMPK cascade is switched on by metabolic stresses that either inhibit
ATP production (eg hypoxia, hypoglycaemia) or that accelerate ATP consumption
(eg muscle contraction). Any decline in cellular energy status is ... Cited by 717 - Related articles - Cached - BL Direct - All 6 versions
- ►cell.com BB Kahn, T Alquier, D Carling, DG Hardie - Cell metabolism, 2005 - Elsevier The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of
cellular energy status, and recent data demonstrate that it also plays a
critical role in systemic energy balance. AMPK integrates nutritional and ... Cited by 641 - Related articles - All 11 versions
- ►biologists.org DG Hardie - Journal of cell science, 2004 - jcs.biologists.org The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy
status. Whenever the cellular ATP:ADP ratio falls, owing to a stress that
inhibits ATP production or increases ATP consumption, this is amplified by ... Cited by 346 - Related articles - BL Direct - All 12 versions
- ►nih.gov DG Hardie, SA Hawley, JW Scott - The Journal of physiology, 2006 - Physiological Soc The LKB1→AMPK cascade is switched on by metabolic stresses that either inhibit
ATP production (eg hypoxia, hypoglycaemia) or that accelerate ATP consumption
(eg muscle contraction). Any decline in cellular energy status is ... Cited by 220 - Related articles - BL Direct - All 8 versions
DG Hardie, K Sakamoto - Physiology, 2006 - Am Physiological Soc It has been known for many years that exercise and contraction induces marked
changes in the metabolism of skeletal muscle, including increases in glycogen
breakdown, glycolysis, glucose uptake, and fatty acid oxidation, together ... Cited by 135 - Related articles - BL Direct - All 5 versions
DL Feinstein, A Spagnolo, C Akar, G … - Biochemical Pharmacology, 2005 - Elsevier Agonists of the peroxisome proliferator activated receptor gamma (PPARγ) are
currently used for treatment of type 2 diabetes due to their insulin sensitizing
and glucose metabolism stabilizing effects. More recently some of these ... Cited by 127 - Related articles - All 4 versions
- ►pitt.edu [PDF] M Collino, M Aragno, R Mastrocola, M … - European journal of pharmacology, 2006 - Elsevier Agonists of the peroxisome proliferator-activated receptor-γ (PPAR-γ) exert
protective effects in several models of ischemia/reperfusion injury, but their
role in stroke is less clear. The study investigates the effects of two ... Cited by 77 - Related articles - All 5 versions
- ►physiology.org NK LeBrasseur, M Kelly, TS Tsao, SR … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Thiazolidinediones (TZDs) are insulin-sensitizing agents used in the treatment
of type 2 diabetes. A widely held view is that their action is secondary to
transcriptional events that occur when TZDs bind to the nuclear receptor ... Cited by 70 - Related articles - BL Direct - All 3 versions
- ►shouxi.net D Detaille, B Guigas, C Chauvin, C Batandier … - Diabetes, 2005 - Am Diabetes Assoc Hyperglycemia-induced oxidative stress is detrimental for endothelial cells,
contributing to the vascular complications of diabetes. The mitochondrial
permeability transition pore (PTP) is an oxidative stress–sensitive ... Cited by 46 - Related articles - All 5 versions
D Konrad, A Rudich, PJ Bilan, N Patel, C … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Troglitazone was the first thiazolidinedione (TZD)
approved for clinical use, exerting hypoglycaemic effects related to its action
as a ligand of the peroxisome proliferator-activated receptor γ receptor ... Cited by 40 - Related articles - All 3 versions
