- ►physiology.org AMW Petersen, BK Pedersen - Journal of Applied Physiology, 2005 - Am Physiological Soc Regular exercise offers protection against all-cause mortality, primarily by protection against
cardiovascular disease and Type 2 diabetes mellitus. The latter disorders have been associated
with chronic low-grade systemic inflammation reflected by a two- to threefold elevated ... Cited by 323 - Related articles - All 10 versions
- ►nih.gov CN Lumeng, JL Bodzin, AR Saltiel - Journal of Clinical …, 2007 - Am Soc Clin Investig Adipose tissue macrophages (ATMs) infiltrate adipose tissue during obesity and contribute to
insulin resistance. We hypothesized that macrophages migrating to adipose tissue upon
high-fat feeding may differ from those that reside there under normal diet conditions. To ... Cited by 241 - Related articles - BL Direct - All 9 versions
- ►nih.gov JK Kim, JJ Fillmore, MJ Sunshine, B … - Journal of Clinical …, 2004 - Am Soc Clin Investig Insulin resistance plays a primary role in the development of type 2 diabetes and may be related
to alterations in fat metabolism. Recent studies have suggested that local accumulation of fat
metabolites inside skeletal muscle may activate a serine kinase cascade involving protein ... Cited by 176 - Related articles - BL Direct - All 8 versions
- ►nih.gov NK Lee, H Sowa, E Hinoi, M Ferron, JD Ahn, C … - Cell, 2007 - Elsevier The regulation of bone remodeling by an adipocyte-derived hormone implies that bone may
exert a feedback control of energy homeostasis. To test this hypothesis we looked for genes
expressed in osteoblasts, encoding signaling molecules and affecting energy ... Cited by 166 - Related articles - All 14 versions
SE Shoelson, L Herrero, A Naaz - Gastroenterology, 2007 - Elsevier Weight gain and obesity are major risk factors for conditions and diseases ranging from insulin
resistance and type 2 diabetes mellitus to atherosclerosis and the sequelae of nonalcoholic fatty
liver disease. A chronic, subacute state of inflammation often accompanies the ... Cited by 149 - Related articles - All 23 versions
- ►nursing2008.com L Hutley, JB Prins - The American journal of the medical sciences, 2005 - journals.lww.com ABSTRACT: Obesity and the metabolic syndrome have both reached pandemic proportions.
Together they have the potential to impact on the incidence and severity of cardiovascular
pathologies, with grave implications for worldwide health care systems. The metabolic ... Cited by 116 - Related articles - All 6 versions
PA Tataranni, E Ortega - Diabetes, 2005 - Am Diabetes Assoc There is growing support for the hypothesis that obesity is an inflammatory condition leading
to chronic activation of the innate immune system, which ultimately causes progressive impairment
of glucose tolerance. Experimental studies in animals and evidence from prospective and ... Cited by 103 - Related articles - All 9 versions
AL Carey, GR Steinberg, SL Macaulay, WG Thomas, … - Diabetes, 2006 - Am Diabetes Assoc Although interleukin-6 (IL-6) has been associated with insulin resistance, little is known regarding
the effects of IL-6 on insulin sensitivity in humans in vivo. Here, we show that IL-6 infusion increases
glucose disposal without affecting the complete suppression of endogenous glucose ... Cited by 99 - Related articles - BL Direct - All 6 versions
PJ Klover, AH Clementi, RA Mooney - Endocrinology, 2005 - Endocrine Soc Obesity and insulin resistance are considered chronic inflammatory states, in part because circulating
IL-6 is elevated. Exogenous IL-6 can induce hepatic insulin resistance in vitro and in vivo. The
importance of endogenous IL-6, however, to insulin resistance of obesity is unresolved. ... Cited by 93 - Related articles - BL Direct - All 5 versions
