NE Zachara, GW Hart - BBA-Molecular and Cell Biology of Lipids, 2006 - Elsevier An increasing body of evidence points to a central regulatory role for glucose in mediating cellular
processes and expands the role of glucose well beyond its traditional role(s) in energy
metabolism. Recently, it has been recognized that one downstream effector produced ... Cited by 79 - Related articles - All 4 versions
- ►ahajournals.org Y Hu, D Belke, J Suarez, E Swanson, R Clark, M … - Circulation …, 2005 - Am Heart Assoc To examine whether excessive protein O-GlcNAcylation plays a role in the dysfunction of the
diabetic heart, we delivered adenovirus expressing O-GlcNAcase (Adv-GCA) into the myocardium
of STZ-induced diabetic mice. Our results indicated that excessive cellular ... Cited by 43 - Related articles - All 6 versions
J Liu, Y Pang, T Chang, P Bounelis, JC Chatham, … - Journal of molecular and …, 2006 - Elsevier Increased hexosamine biosynthesis pathway (HBP) flux and elevated levels of protein
O-linked-N-acetylglucosamine (O-GlcNAc) decrease calcium influx into isolated
cardiomyocytes. Increased O-GlcNAc levels also increase tolerance of cells to stress. ... Cited by 37 - Related articles - All 7 versions
- ►cardiovascres.org N Fulop, RB Marchase, JC Chatham - Cardiovascular research, 2007 - cardiovascres.org There is growing recognition that the O-linked attachment of N-acetyl-glucosamine
(O-GlcNAc) on serine and threonine residues of nuclear and cytoplasmic proteins is a highly
dynamic post-translational modification that plays a key role in signal transduction ... Cited by 36 - Related articles - All 7 versions
- ►physiology.org T Nagy, V Champattanachai, RB … - American Journal of …, 2006 - Am Physiological Soc We previously reported that glucosamine and hyperglycemia attenuate the response of cardiomyocytes
to inositol 1,4,5-trisphosphate-generating agonists such as ANG II. This appears to be related
to an increase in flux through the hexosamine biosynthesis pathway (HBP) and ... Cited by 31 - Related articles - BL Direct - All 3 versions
- ►physiology.org V Champattanachai, RB Marchase, JC … - American Journal of …, 2007 - Am Physiological Soc Increased levels of protein O-linked N-acetylglucosamine (O-GlcNAc) have been shown to increase
cell survival following stress. Therefore, the goal of this study was to determine whether in isolated
neonatal rat ventricular myocytes (NRVMs) an increase in protein O-GlcNAcylation ... Cited by 29 - Related articles - BL Direct - All 6 versions
- ►nih.gov J Liu, RB Marchase, JC Chatham - Journal of molecular and cellular cardiology, 2007 - Elsevier It has been shown that glutamine protects the heart from ischemia/reperfusion (I/R) injury;
however, the mechanisms underlying this protection have not been identified.
Glutamine:fructose-6-phosphate amidotransferase (GFAT) regulates the entry of glucose ... Cited by 20 - Related articles - All 18 versions
- ►critcaremed.com S Yang, L Zou, P Bounelis, I Chaudry, JC Chatham, RB … - Shock, 2006 - journals.lww.com Received 17 Oct 2005; first review completed 10 Nov 2005; accepted in final form 3 Jan 2006
ABSTRACT—Stress-induced hyperglycemia is necessary for maximal rates of survival after severe
hemorrhage; however, the responsible mechanisms are not clear. One consequence of ... Cited by 20 - Related articles - BL Direct - All 8 versions
- ►physiology.org N Fulop, MM Mason, K Dutta, P Wang, AJ … - American Journal of …, 2007 - Am Physiological Soc Increased levels of O-linked attachment of N-acetylglucosamine (O-GlcNAc) on nucleocytoplasmic
proteins are implicated in the development of diabetic cardiomyopathy and are regulated by
O-GlcNAc transferase (OGT) expression and its substrate UDP-GlcNAc. Therefore, the ... Cited by 16 - Related articles - BL Direct - All 5 versions
DW Cheng, Y Jiang, A Shalev, R Kowluru, … - … of Physiology and …, 2006 - informahealthcare.com Renal mesangial cells play an important role in the development of diabetic kidney disease.
We have previously demonstrated that some of the effects of high glucose on mesangial extracellular
matrix (ECM) protein expression are mediated by the hexosamine biosynthesis pathway ( ... Cited by 14 - Related articles - BL Direct - All 4 versions
