K Maedler, J Størling, J Sturis, RA Zuellig … - Diabetes, 2004 - Am Diabetes Assoc Increasing evidence indicates that a progressive decrease in the functional
β-cell mass is the hallmark of both type 1 and type 2 diabetes. The underlying
causes, β-cell apoptosis and impaired secretory function, seem to be ... Cited by 36 - Related articles - All 3 versions
- ►nih.gov A Jahangir, A Terzic - Journal of molecular and cellular cardiology, 2005 - Elsevier The family of potassium channel openers regroups drugs that share the property
of activating adenosine triphosphate-sensitive potassium (K ATP ) channels,
metabolic sensors responsible for adjusting membrane potential-dependent ... Cited by 26 - Related articles - All 12 versions
- ►wisc.edu [PDF] SM Clee, ST Nadler, AD Attie - American journal of therapeutics, 2005 - journals.lww.com The BTBR mouse strain harbors alleles promoting insulin resistance. When made
genetically obese (ob/ob), these mice develop severe type 2 diabetes (fasting
glucose .400 mg/dL). By contrast, C57BL/6 ob/ob mice are able to compensate ... Cited by 16 - Related articles - BL Direct - All 7 versions
- ►physiology.org ME Rabaglia, MP Gray-Keller, BL Frey, MR … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc Most patients at risk for developing type 2 diabetes are hyperinsulinemic.
Hyperinsulinemia may be a response to insulin resistance, but another possible
abnormality is insulin hypersecretion. BTBR mice are insulin resistant and ... Cited by 13 - Related articles - BL Direct - All 6 versions
- ►nih.gov HK Haider, M Ashraf - Journal of molecular and cellular cardiology, 2008 - Elsevier Stem cell transplantation has emerged as a potential modality in cardiovascular
therapeutics due to their inherent characteristics of self-renewal, unlimited
capacity for proliferation and ability to cross lineage restrictions and ... Cited by 13 - Related articles - All 20 versions
K Buschard, M Blomqvist, T Osterbye, P … - Diabetologia, 2005 - Springer Abstract Mammalian tissues express β-isoforms of gly- cosphingolipids and,
among these, sulfatide (sulphated galactosylceramide) is present in the beta
cells, and it is here that the short fatty acid chain (C16) isoform is pre- ... Cited by 10 - Related articles - BL Direct - All 3 versions
- ►endojournals.org W El-Kholy, PE MacDonald, JM Fox, A … - Molecular Endocrinology, 2007 - Endocrine Soc Hyperpolarization-activated cyclic nucleotide-modulated (HCN) channels mediate
the pacemaker current (I h or I f ) observed in electrically rhythmic cardiac
and neuronal cells. Here we describe a hyperpolarization-activated time- ... Cited by 8 - Related articles - BL Direct - All 4 versions
FE Nielsen, P Jacobsen, A Worsaae, POG … - Bioorganic & Medicinal Chemistry Letters, 2004 - Elsevier Only a few different structural types of activators of Kir6.2/SUR1 potassium
channels have been described. These include the 1,2,4-thiadiazine 1,1-dioxide
derivatives like diazoxide, BPDZ 62, BPDZ 73 and NN414 [1] , [2] , [3] and ... Cited by 7 - Related articles - All 3 versions
M Blomqvist, M Carrier, T Andrews, K … - Diabetes/Metabolism Reviews - interscience.wiley.com Sulfatide is present in the secretory granules of beta cells and has been shown,
in vitro, to be involved in insulin processing and secretion. Of particular
interest is one of the major sulfatide isoforms in the beta cells, the ... Cited by 6 - Related articles - All 2 versions
MO Larsen, B Rolin, CF Gotfredsen, RD Carr, … - Diabetologia, 2004 - Springer Aims/hypothesis. A progressive loss of beta cell func- tion and mass are
important contributory factors in the development and progression of type 2
diabetes. The aim of this study was to evaluate the effects of a pri- mary ... Cited by 5 - Related articles - All 3 versions
