- ►daegu.ac.kr [PDF] R Sladek, G Rocheleau, J Rung, C Dina, L … - Nature, 2007 - nature.com Type 2 diabetes mellitus results from the interaction of environmental factors
with a combination of genetic variants, most of which were hitherto unknown. A
systematic search for these variants was recently made possible by the ... Cited by 770 - Related articles - BL Direct - All 14 versions
- ►missouri.edu [PDF] AT Hattersley, MI McCarthy - The Lancet, 2005 - Elsevier Genetic association studies are central to efforts to identify and characterise
genomic variants underlying susceptibility to multifactorial disease. However,
obtaining robust replication of initial association findings has proved ... Cited by 232 - Related articles - All 9 versions
- ►umich.edu [PDF] K Silander, KL Mohlke, LJ Scott, EC Peck, P … - Diabetes, 2004 - Am Diabetes Assoc The Finland-United States Investigation Of NIDDM Genetics (FUSION) study aims to
identify genetic variants that predispose to type 2 diabetes by studying
affected sibling pair families from Finland. Chromosome 20 showed our ... Cited by 204 - Related articles - BL Direct - All 10 versions
S Cauchi, D Meyre, C Dina, H Choquet, C … - Diabetes, 2006 - Am Diabetes Assoc Recently, the transcription factor 7-like 2 (TCF7L2) gene has been associated
with type 2 diabetes in subjects of European origin in the DeCode study. We
genotyped the two most associated variants (rs7903146 and rs12255372) in ... Cited by 149 - Related articles - BL Direct - All 3 versions
- ►usc.edu [PDF] S O'Rahilly, I Barroso, NJ Wareham - Science, 2005 - sciencemag.org The intensive search for genetic variants that predispose to type 2 diabetes was
launched with optimism, but progress has been slower than was hoped. Even so,
major advances have been made in the understanding of monogenic forms of ... Cited by 114 - Related articles - All 11 versions
I Barroso - Diabetic medicine, 2005 - interscience.wiley.com Type 2 diabetes (T2D) has become a health-care problem worldwide, with the rise
in disease prevalence being all the more worrying as it not only affects the
developed world but also developing nations with fewer resources to cope ... Cited by 101 - Related articles - All 6 versions
- ►nih.gov MA Permutt, J Wasson, N Cox - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Conventional genetic analysis focuses on the genes that account for specific
phenotypes, while traditional epidemiology is more concerned with the
environmental causes and risk factors related to traits. Genetic ... Cited by 90 - Related articles - All 9 versions
- ►diabetesjournals.org MN Weedon, KR Owen, B Shields, G Hitman, M … - Diabetes, 2004 - Am Diabetes Assoc Hepatocyte nuclear factor (HNF)-4α is part of a transcription factor network
that is key for the development and function of the β-cell. Rare mutations in
the HNF4α gene cause maturity-onset diabetes of the young. A number of ... Cited by 85 - Related articles - BL Direct - All 5 versions
- ►nih.gov RK Gupta, MZ Vatamaniuk, CS Lee, RC … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Mutations in the gene encoding hepatocyte nuclear factor-4α (HNF-4α) result in
maturity-onset diabetes of the young (MODY). To determine the contribution of
HNF-4α to the maintenance of glucose homeostasis by the β cell in vivo, ... Cited by 75 - Related articles - All 7 versions
MS Sandhu, MN Weedon, KA Fawcett, J Wasson … - Nature genetics, 2007 - pubmedcentral.nih.gov I. Barroso, ATH, MAP, NJW and MSS designed this study; MSS did the statistical
analysis, supported by I. Barroso, AD, SLD, KAF, HL, RJN, PDP, RS and MNWMSS
wrote the manuscript with I. Barroso, SLD and KAF; AD conducted the ... Cited by 77 - Related articles - BL Direct - All 11 versions
