D Smyth, JD Cooper, JE Collins, JM Heward, JA … - Diabetes, 2004 - Am Diabetes Assoc In the genetic analysis of common, multifactorial diseases, such as type 1 diabetes, true positive
irrefutable linkage and association results have been rare to date. Recently, it has been reported
that a single nucleotide polymorphism (SNP), 1858C>T, in the gene PTPN22, encoding ... Cited by 244 - Related articles - BL Direct - All 5 versions
- ►nih.gov A Vella, JD Cooper, CE Lowe, N Walker, S Nutland, … - The American Journal of …, 2005 - Elsevier Despite hundreds of association studies, few have been consistently replicated (Dahlman et
al. 2002; Hirschhorn et al. 2003; Ioannidis et al. 2003; Lohmueller et al. 2003). In type 1 diabetes
(T1D [MIM 222100]), only four loci have been identified and successfully replicated: the ... Cited by 137 - Related articles - All 6 versions
JH Chae, GH Stein, JE Lee - Mol Cells, 2004 - ksmb.or.kr NeuroD (otherwise known as BETA2) is a basic helix- loop-helix (bHLH) transcription factor that
is capable of converting embryonic epidermal cells into fully dif- ferentiated neurons in Xenopus
embryos. In insulin- oma cells, NeuroD can bind and activate the insulin promoter. When ... Cited by 48 - Related articles - View as HTML - All 5 versions
E Kawasaki, N Matsuura, K Eguchi - Diabetologia, 2006 - Springer Abstract Type 1 diabetes is a multifactorial disease which results from a T-cell-mediated autoimmune
destruction of the pancreatic beta cells in genetically predisposed individuals. The risk for individuals
of developing type 1 diabetes varies remarkably according to country of residence and ... Cited by 28 - Related articles - BL Direct - All 3 versions
JMM Howson, BJ Barratt, JA Todd, HJ … - Genetic …, 2005 - interscience.wiley.com We compared different ascertainment schemes for genetic association analysis: affected
sib-pairs (ASPs), case-parent trios, and unrelated cases and controls. We found, with empirical
type 1 diabetes data at four known disease loci, that studies based on case-parent trios ... Cited by 23 - Related articles - BL Direct - All 3 versions
JS Szeszko, JMM Howson, JD Cooper, NM Walker, … - Diabetes, 2006 - Am Diabetes Assoc Recently, the interleukin-18 cytokine gene (IL18) was reported to be associated with type 1
diabetes. In the present report, we calculated that the reported genotypes of the two 5′
region/promoter single nucleotide polymorphisms (SNPs), −607 (C→A) (rs1946518) and ... Cited by 19 - Related articles - BL Direct - All 6 versions
- ►nih.gov LM Maier, J Chapman, JMM Howson, DG Clayton, … - The American Journal of …, 2005 - Elsevier Attempts to identify susceptibility loci that, on their own, have marginal main effects by use of
gene-gene interaction tests have increased in popularity. The results obtained from analyses
of epistasis are, however, difficult to interpret. Gene-gene interaction, albeit only ... Cited by 17 - Related articles - All 6 versions
FK Kavvoura, JPA Ioannidis - Human genetics, 2005 - Springer Abstract A meta-analysis assessed whether the Ala45Thr polymorphism of the neurogenic
differentia- tion 1 (NEUROD1) gene is associated with increased risk of diabetes mellitus type
1 (T1D) or type 2 (T2D). Fourteen case-control studies were analyzed, including genotype ... Cited by 14 - Related articles - All 4 versions
LM Maier, DJ Smyth, A Vella, F Payne, JD Cooper, R … - BMC genetics, 2005 - biomedcentral.com One strategy to help identify susceptibility genes for complex, multifactorial diseases is to map
disease loci in a representative animal model of the disorder. The nonobese diabetic (NOD)
mouse is a model for human type 1 diabetes. Linkage and congenic strain analyses have ... Cited by 10 - Related articles - Cached - All 6 versions
