KG Ewens, RA George, K Sharma, FN Ziyadeh, RS … - Diabetes, 2005 - Am Diabetes Assoc Several lines of evidence, including familial aggregation, suggest that allelic variation contributes
to risk of diabetic nephropathy. To assess the evidence for specific susceptibility genes, we used
the transmission/disequilibrium test (TDT) to analyze 115 candidate genes for linkage ... Cited by 34 - Related articles - BL Direct - All 5 versions
H Rincon-Choles, F Thameem, DM Lehman, … - American journal of …, 2005 - journals.lww.com Diabetes mellitus is the leading cause of end-stage renal disease. Development and progression
of diabetic nephropathy result from a combination of genetic susceptibility and metabolic and
hemodynamic abnormalities. In America, some racial and ethnic minorities have a ... Cited by 11 - Related articles - BL Direct - All 5 versions
- ►oxfordjournals.org BR Conway, DA Savage, A Peter Maxwell - Nephrology Dialysis …, 2006 - ERA-EDTA Diabetic nephropathy is the leading cause of end-stage renal disease in the Western world
[1], placing considerable demands on health care resources and causing significant morbidity
and mortality for individuals with diabetes. Improvements in glycaemic and blood ... Cited by 6 - Related articles - BL Direct - All 5 versions
BR Conway, DA Savage, HR Brady, AP … - Nephron Exp …, 2007 - content.karger.com Background/Aims: The Hp 1 /Hp 2 DNA polymorphism has previously been implicated in susceptibility
to diabetic nephropathy in some but not all studies. In an attempt to clarify these conflicting
findings, we conducted a case-control association study in a Caucasian population. ... Cited by 4 - Related articles - BL Direct - All 5 versions
G Li, A Rajala, AF Wiechmann, RE … - Journal of …, 2008 - ingentaconnect.com Akt is a phospholipid-binding protein and the downstream effector of the phosphoinositide
3-kinase (PI3K) pathway. Akt has three isoforms: Akt1, Akt2, and Akt3. All of these isoforms are
expressed in rod photoreceptor cells, but the individual functions of each isoform are not ... Cited by 2 - Related articles - All 2 versions
M Murphy, J Crean, D Brazil, D Sadlier, F … - Biochemical Society …, 2008 - biochemsoctrans.org DN (diabetic nephropathy) is the leading cause of end-stage renal disease worldwide and develops
in 25–40% of patients with Type 1 or Type 2 diabetes mellitus. Elevated blood glucose over long
periods together with glomerular hypertension leads to progressive glomerulosclerosis ... Cited by 2 - Related articles - Cached - All 4 versions
RVS Rajala, A Rajala, RS Brush, NP … - Journal of …, 2009 - pubmedcentral.nih.gov The insulin receptor (IR) and IR signaling proteins are widely distributed throughout the central
nervous system. IR signaling provides a trophic signal for transformed retinal neurons in culture
and we recently reported that deletion of IR in rod photoreceptors by Cre/lox system ... Cited by 1 - Related articles - All 4 versions
RVS Rajala - J Proteomics Bioinform, 2008 - omicsonline.com Neurodegeneration is an important component of diabetic retinopathy as demonstrated by increased
neural apoptosis in the retina during experimental and human diabetes. Accumulation of sorbitol
and fructose and the generation or enhancement of oxidative stress has been reported in ... Related articles - Cached - All 3 versions
RVS Rajala, A Rajala - Chemico-Biological Interactions, 2009 - Elsevier Insulin receptor (IR) signaling provides a trophic signal for transformed retinal neurons in
culture, and we recently reported that deletion of IR from rod photoreceptors resulted in
stress-induced photoreceptor degeneration. Retinal insulin receptor has a high basal ... Related articles - All 2 versions
