- ►nih.gov MA Permutt, J Wasson, N Cox - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Conventional genetic analysis focuses on the genes that account for specific phenotypes, while
traditional epidemiology is more concerned with the environmental causes and risk factors related
to traits. Genetic epidemiology is an alliance of the 2 fields that focuses on both genetics, ... Cited by 91 - Related articles - All 9 versions
- ►nih.gov HF Lin, B Boden-Albala, SH Juo, N Park, T Rundek, RL … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Growing evidence suggests that the traits comprising the metabolic
syndrome have a genetic basis. However, studies of genetic contributions to the syndrome are
sparse. Against this background, we sought to estimate the heritability of the metabolic ... Cited by 48 - Related articles - BL Direct - All 8 versions
- ►ahajournals.org RM Krauss - Arteriosclerosis, thrombosis, and vascular biology, 2005 - Am Heart Assoc A goal of dietary management of cardiovascular disease risk in patients with obesity and metabolic
syndrome is improvement in the atherogenic dyslipidemia comprising elevated triglyceride, reduced
high-density lipoprotein (HDL) cholesterol, and increased numbers of small, dense low- ... Cited by 37 - Related articles - All 7 versions
RL Pollex, RA Hegele - Nature Clinical Practice Cardiovascular Medicine, 2006 - nature.com Robert A Hegele is a professor of medicine and biochemistry at the Schulich School of Medicine
and Dentistry, University of Western Ontario, London, ON, Canada, and is the Director of the
Blackburn Cardiovascular Genetics Laboratory at Robarts Research Institute, London, ... Cited by 38 - Related articles - All 3 versions
JJ McCarthy - Nutrition, Metabolism and Cardiovascular Diseases, 2007 - Elsevier Despite decades of research, the genetic basis of coronary heart disease and its metabolic risk
factors is poorly understood. Few studies consider that sex may modify the effect of gene variants
on disease. Investigation of gene by sex interaction may help to elucidate underlying ... Cited by 25 - Related articles - All 13 versions
M Uusitupa - Nutrition, Metabolism and Cardiovascular Diseases, 2005 - Elsevier Both genetic and environmental factors are involved in the pathogenesis of obesity and type
2 diabetes. Most of the genetic studies on common obesity are confined to the links between
a given gene polymorphism or gene loci and different phenotypes of obesity or ... Cited by 23 - Related articles - BL Direct - All 7 versions
RA Bayoumi, SAS Al-Yahyaee, SA Albarwani, SG Rizvi … - Obesity, 2007 - nature.com The metabolic syndrome, as defined by the International Diabetes Federation, was investigated
in five large, extended, highly consanguineous, healthy Omani Arab families of a total of 1277
individuals. Heritability (h 2 ) of the phenotypic abnormalities that make up the syndrome ... Cited by 21 - Related articles - All 2 versions
- ►ahajournals.org AT Kraja, DC Rao, AB Weder, R Cooper, JD Curb, CL … - Hypertension, 2005 - Am Heart Assoc Genome-wide variance components linkage analysis was performed on 4 latent factors underlying
metabolic syndrome derived from 10 risk factors. The latent factors represent obesity and
insulin, blood pressure, lipids and insulin, and central obesity. The metabolic syndrome ... Cited by 19 - Related articles - All 13 versions
MA Wörns, A Victor, PR Galle, T Höhler - Genes and Immunity, 2006 - nature.com Elevated baseline levels of acute-phase proteins such as C-reactive protein (CRP) or cytokines
like interleukin-6 (IL-6) are known risk factors for atherosclerosis and cardiovascular disease
(CVD) events. However, until today, there is only controversial information about the ... Cited by 19 - Related articles - BL Direct - All 3 versions
M Terán-García, C Bouchard - Applied Physiology, Nutrition, …, 2007 - article.pubs.nrc-cnrc.gc.ca Abstract: The concept of a metabolic syndrome (MetS), a cluster of pre-clinical metabolic alterations
commonly associ- ated with obesity, is the object of much debate. Genetic studies have the potential
to contribute to some of the key ques- tions, including the true nature of the cluster of pre- ... Cited by 17 - Related articles - BL Direct - All 5 versions
