- ►nih.gov K Ma, PK Saha, L Chan, DD Moore - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The bile acid receptor farnesoid X receptor (FXR; NR1H4) is a central regulator
of bile acid and lipid metabolism. We show here that FXR plays a key regulatory
role in glucose homeostasis. FXR-null mice developed severe fatty liver and ... Cited by 112 - Related articles - BL Direct - All 9 versions
- ►nih.gov Y Zhang, FY Lee, G Barrera, H Lee, C Vales, … - Proceedings of the National Academy of Sciences of …, 2006 - National Acad Sciences Farnesoid X receptor (FXR) plays an important role in maintaining bile acid and
cholesterol homeostasis. Here we demonstrate that FXR also regulates glucose
metabolism. Activation of FXR by the synthetic agonist GW4064 or hepatic ... Cited by 114 - Related articles - BL Direct - All 10 versions
SM Houten, M Watanabe, J Auwerx - The EMBO journal, 2006 - pubmedcentral.nih.gov Bile acids (BAs), a group of structurally diverse molecules that are primarily
synthesized in the liver from cholesterol, are the chief components of bile.
Besides their well-established roles in dietary lipid absorption and ... Cited by 84 - Related articles - BL Direct - All 11 versions
T Claudel, B Staels, F Kuipers - Arteriosclerosis, thrombosis, and vascular biology, 2005 - Am Heart Assoc Bile acids are the end products of cholesterol metabolism. They are synthesized
in the liver and secreted via bile into the intestine, where they aid in the
absorption of fat-soluble vitamins and dietary fat. Subsequently, bile ... Cited by 76 - Related articles - All 6 versions
- ►shouxi.net B Cariou, K van Harmelen, D Duran-Sandoval, … - Journal of Biological Chemistry, 2006 - ASBMB The farnesoid X receptor (FXR) is a bile acid (BA)-activated nuclear receptor
that plays a major role in the regulation of BA and lipid metabolism. Recently,
several studies have suggested a potential role of FXR in the control of ... Cited by 69 - Related articles - BL Direct - All 7 versions
- ►endojournals.org KR Stayrook, KS Bramlett, RS Savkur, J … - Endocrinology, 2005 - Endocrine Soc The farnesoid X receptor (FXR; NR1H4) is a nuclear hormone receptor that
functions as the bile acid receptor. In addition to the critical role FXR plays
in bile acid metabolism and transport, it regulates a variety of genes ... Cited by 67 - Related articles - All 5 versions
FY Lee, H Lee, ML Hubbert, PA Edwards, Y … - Trends in biochemical sciences, 2006 - Elsevier The farnesoid X receptor (FXR) is a ligand-activated transcription factor and a
member of the nuclear receptor superfamily. In the past six years, remarkable
inroads have been made into determining the functional importance of FXR. ... Cited by 53 - Related articles - All 7 versions
- ►jbc.org D Duran-Sandoval, B Cariou, F Percevault, N … - Journal of Biological Chemistry, 2005 - ASBMB The liver plays a central role in the control of blood glucose homeostasis by
maintaining a balance between glucose production and utilization. The farnesoid
X receptor (FXR) is a bile acid-activated nuclear receptor. Hepatic FXR ... Cited by 35 - Related articles - BL Direct - All 5 versions
- ►jlr.org EA Hanniman, G Lambert, TC McCarthy, CJ … - The Journal of Lipid Research, 2005 - ASBMB The farnesoid X receptor (FXR) is a bile acid-activated transcription factor
that regulates the expression of genes critical for bile acid and lipid
homeostasis. This study was undertaken to investigate the pathological ... Cited by 34 - Related articles - BL Direct - All 5 versions
R Pellicciari, G Costantino, S Fiorucci - Journal of medicinal chemistry, 2005 - course.ucsf.edu 1. Introduction The human nuclear receptor (NR) family consists of 48
transcription factors divided into seven classes (Table 1) and activated by a
large variety of ligands such as steroids, retinoids, vitamin D, thyroid ... Cited by 34 - Related articles - View as HTML - All 7 versions
