NE Zachara, GW Hart - BBA-Molecular and Cell Biology of Lipids, 2006 - Elsevier An increasing body of evidence points to a central regulatory role for glucose in mediating cellular
processes and expands the role of glucose well beyond its traditional role(s) in energy
metabolism. Recently, it has been recognized that one downstream effector produced ... Cited by 79 - Related articles - All 4 versions
HKR Karlsson, JR Zierath, S Kane, A Krook, GE … - Diabetes, 2005 - Am Diabetes Assoc AS160 is a newly described substrate for the protein kinase Akt that links insulin signaling and
GLUT4 trafficking. In this study, we determined the expression of and in vivo insulin action on
AS160 in human skeletal muscle. In addition, we compared the effect of physiological ... Cited by 78 - Related articles - All 5 versions
- ►jbc.org MS Macauley, GE Whitworth, AW Debowski, D Chin … - Journal of Biological …, 2005 - ASBMB The post-translational modification of serine and threonine residues of nucleocytoplasmic proteins
with 2-acetamido-2-deoxy-D-glucopyranose (GlcNAc) is a reversible process implicated in multiple
cellular processes. The enzyme O-GlcNAcase catalyzes the cleavage of -O-linked ... Cited by 68 - Related articles - All 5 versions
X Yang, PP Ongusaha, PD Miles, JC Havstad, F … - NATURE- …, 2008 - sethfield.ucsd.edu Glucose flux through the hexosamine biosynthetic pathway leads to the post-translational modification
of cytoplasmic and nuclear proteins by O-linked bN-acetylglucosamine (O-GlcNAc). This tandem
system serves as a nutrient sensor to couple systemic metabolic status to cellular ... Cited by 51 - Related articles - View as HTML - BL Direct - All 8 versions
A Deshmukh, VG Coffey, Z Zhong, AV Chibalin, JA … - Diabetes, 2006 - Am Diabetes Assoc Skeletal muscle contraction stimulates multiple signaling cascades that govern a variety of metabolic
and transcriptional events. Akt/protein kinase B regulates metabolism and growth/muscle
hypertrophy, but contraction effects on this target and its substrates are varied and may ... Cited by 44 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org DM Lehman, DJ Fu, AB Freeman, KJ Hunt, RJ Leach, T … - Diabetes, 2005 - Am Diabetes Assoc Excess O-glycosylation of proteins by O-linked β-N-acetylglucosamine (O-GlcNAc) may be involved
in the pathogenesis of type 2 diabetes. The enzyme O-GlcNAc–selective N-acetyl-β-d glucosaminidase
(O-GlcNAcase) encoded by MGEA5 on 10q24.1-q24.3 reverses this modification by ... Cited by 43 - Related articles - All 5 versions
SY Park, J Ryu, W Lee - Exp Mol Med, 2005 - e-emm.or.kr 1From the Department of Biochemistry College of Medicine, Dongguk University Gyeongju
780-714, Korea 2Biophysics Laboratory Veteran Affairs Medical Center Department of Physiology
and Biophysics School of Medicine, State University of New York at Buffalo Buffalo, NY ... Cited by 35 - Related articles - View as HTML - All 13 versions
E Oh, BA Spurlin, JE Pessin, DC Thurmond - Diabetes, 2005 - Am Diabetes Assoc The disruption of Munc18c binding to syntaxin 4 impairs insulin-stimulated GLUT4 vesicle translocation
in 3T3L1 adipocytes. To investigate the physiological function and requirement for Munc18c
in the regulation of GLUT4 translocation and glucose homeostasis in vivo, we used ... Cited by 34 - Related articles - All 6 versions
- ►physiology.org T Nagy, V Champattanachai, RB … - American Journal of …, 2006 - Am Physiological Soc We previously reported that glucosamine and hyperglycemia attenuate the response of cardiomyocytes
to inositol 1,4,5-trisphosphate-generating agonists such as ANG II. This appears to be related
to an increase in flux through the hexosamine biosynthesis pathway (HBP) and ... Cited by 31 - Related articles - BL Direct - All 3 versions
- ►jbc.org ZT Kneass, RB Marchase - Journal of Biological Chemistry, 2005 - ASBMB The modification of serine/threonine residues on cytoplasmic and nuclear proteins by N-acetylglucosamine
(O-GlcNAc) is suggested to play a role in the regulation of a variety of signal transduction
pathways. We have previously shown that glucosamine (GlcNH 2 ), a metabolic precursor ... Cited by 30 - Related articles - All 4 versions
