- ►diabetesjournals.org MR Rickels, MH Schutta, JF Markmann, CF Barker, A … - Diabetes, 2005 - Am Diabetes Assoc Islet transplantation can provide metabolic stability for patients with type 1 diabetes;
however, more than one donor pancreas is usually required to achieve insulin
independence. To evaluate possible mechanistic defects underlying impaired graft ... Cited by 55 - Related articles - All 6 versions
A Frank, S Deng, X Huang, E Velidedeoglu, YS … - Annals of …, 2004 - pubmedcentral.nih.gov A striking improvement has taken place in the results of IIT with regard to attaining normoglycemia
and insulin independence of type I diabetic recipients. Theoretically, this minimally invasive therapy
should replace WOP because its risks and expense should be less. To date, however, no ... Cited by 48 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org N Zhang, D Su, S Qu, T Tse, R Bottino, AN … - Diabetes, 2006 - Am Diabetes Assoc Successful islet transplantation depends on the infusion of sufficiently large quantities of
islets, but only a fraction of transplanted islets can survive and become engrafted, and yet the
underlying mechanism remains unclear. In this study, we examined the effect of sirolimus, ... Cited by 42 - Related articles - BL Direct - All 7 versions
- ►jimmunol.org L Wang, R Han, I Lee, AS Hancock, G Xiong, … - The Journal of …, 2005 - Am Assoc Immnol Chemokine receptor blockade can diminish the recruitment of host effector cells and prolong
allograft survival, but little is known of the role of chemokine receptors in promoting host
sensitization. We engrafted fully allogeneic islets into streptozotocin-treated normal mice ... Cited by 16 - Related articles - BL Direct - All 4 versions
J Lau, G Mattsson, C Carlsson, D Nyqvist, M Köhler, PO … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—Insulin content, glucose-stimulated insulin release, (pro)insulin biosynthesis, and
glucose oxidation rate were markedly decreased in islets retrieved from the liver, both when
compared with islets transplanted into the pancreas and endogenous islets. Islets ... Cited by 15 - Related articles - BL Direct - All 5 versions
J Lau, L Jansson, PO Carlsson - American Journal of Transplantation, 2006 - ccmjournal.org Not much is known about the physiology of intraportally transplanted islets. One reason for this
is that it is difficult to study such islets, since they are scattered throughout the liver. We employed
a perfusion technique to characterize the functional properties of syngeneic intrahepatic 1- ... Cited by 16 - Related articles - BL Direct - All 6 versions
- ►endojournals.org MR Rickels, M Kamoun, J Kearns, JF … - Journal of Clinical …, 2007 - Endocrine Soc Results: A 42-yr-old woman with type 1 diabetes who had a living-related kidney transplant received
two intraportal islet infusions of a total 17,525 islet equivalents per kg body weight under
daclizumab, prednisone, tacrolimus, and rapamycin immunosuppression. She became ... Cited by 15 - Related articles - BL Direct - All 4 versions
M Fung, D Thompson, RJ Shapiro, GL Warnock, DK … - Diabetes research and …, 2006 - Elsevier Islet transplantation can improve glycemic control in patients with type 1 diabetes and reduce
or eliminate the need for insulin. Glucagon-like peptide-1 (GLP-1) is an intestinal insulinotropic
hormone that augments glucose induced insulin secretion, and has a trophic effect on ... Cited by 14 - Related articles - All 7 versions
G Mattsson, A Danielsson, V Kriz, PO Carlsson, L … - Pancreatology, 2006 - content.karger.com Transplantation of isolated pancreatic islets can be used to cure patients with type 1 diabetes
mellitus. One major problem with the application of this method is the large number of islets needed
for reversal of the hypergly- cemia [1] . A likely explanation for this is an increased -cell ... Cited by 15 - Related articles - BL Direct - All 4 versions
P Fiorina, A Secchi - Endocrinology and Metabolism Clinics of North …, 2007 - Elsevier Islet cell transplantation recently has emerged as one the most promising therapeutic approaches
to improving glycometabolic control in type 1 diabetic patients, and, in many cases, to obtaining
insulin independence. Islet cell transplantation requires a relatively short hospital stay ... Cited by 13 - Related articles - All 17 versions
