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Scholar Results 1 - 10 of about 80 citing Zhang: Elevated vascular endothelial growth factor production in islets improves islet graft.... (0.13 sec) 

The vascular basement membrane: a niche for insulin gene expression and β cell …

- cell.com
G Nikolova, N Jabs, I Konstantinova, A Domogatskaya, … - Developmental cell, 2006 - Elsevier
Endocrine pancreatic β cells require endothelial signals for their differentiation and function.
However, the molecular basis for such signals remains unknown. Here, we show that β cells,
in contrast to the exocrine pancreatic cells, do not form a basement membrane. Instead, ...
Cited by 77 - Related articles - Library Search - All 18 versions

Vascular Endothelial Growth Factor Increases Functional [beta]-Cell Mass by …


Y Lai, D Schneider, A Kidszun, I Hauck- … - Transplantation, 2005 - journals.lww.com
Transplantation. Wolters Kluwer Health | Lippincott Williams & Wilkins. All Issues. ...
Cited by 47 - Related articles - All 4 versions

Sirolimus is associated with reduced islet engraftment and impaired β-cell function

- diabetesjournals.org
N Zhang, D Su, S Qu, T Tse, R Bottino, AN … - Diabetes, 2006 - Am Diabetes Assoc
Successful islet transplantation depends on the infusion of sufficiently large quantities of
islets, but only a fraction of transplanted islets can survive and become engrafted, and yet the
underlying mechanism remains unclear. In this study, we examined the effect of sirolimus, ...
Cited by 42 - Related articles - BL Direct - All 7 versions

Pancreatic islet production of vascular endothelial growth factor-a is essential for …


M Brissova, A Shostak, M Shiota, PO Wiebe, G … - Diabetes, 2006 - Am Diabetes Assoc
To investigate molecular mechanisms controlling islet vascularization and revascularization
after transplantation, we examined pancreatic expression of three families of angiogenic factors
and their receptors in differentiating endocrine cells and adult islets. Using intravital lectin ...
Cited by 40 - Related articles - BL Direct - All 6 versions

[PDF] Microvascular development: learning from pancreatic islets


I Konstantinova, E Lammert - transplantation, 2004 - duke.edu
Summary Microvascular development is determined by the inter- play between tissue cells and
microvascular endothelial cells. Because the pancreatic islet is an organ composed mainly of
endothelial and endocrine cells, it represents a good model tissue for studying ...
Cited by 40 - Related articles - View as HTML - BL Direct - All 4 versions

Islet Endothelial Cells and Pancreatic {beta}-Cell Proliferation: Studies in Vitro and …

- endojournals.org
M Johansson, G Mattsson, A Andersson, L Jansson, … - Endocrinology, 2006 - Endocrine Soc
The growth of both tumors and nonneoplastic tissues may be influenced by signals from the vascular
endothelium. In the present investigation we show that purified proliferating endothelial cells
from pancreatic islets can stimulate ß-cell proliferation through secretion of hepatocyte ...
Cited by 40 - Related articles - All 5 versions

Biological and biomaterial approaches for improved islet transplantation

- aspetjournals.org
AS Narang, RI Mahato - Pharmacological reviews, 2006 - ASPET
Islet transplantation may be used to treat type I diabetes. Despite tremendous progress in islet
isolation, culture, and preservation, the clinical use of this modality of treatment is limited due
to post-transplantation challenges to the islets such as the failure to revascularize and ...
Cited by 32 - Related articles - BL Direct - All 13 versions

The bioartificial pancreas: progress and challenges

- islet.org [PDF] 
S Kizilel, M Garfinkel, E Opara - Diabetes Technology & Therapeutics, 2005 - liebertonline.com
Diabetes remains a devastating disease, with tremendous cost in terms of human suffering and
healthcare expenditures. A bioartificial pancreas has the potential as a promising approach to
preventing or reversing complications associated with this disease. Bioartificial pancreatic ...
Cited by 29 - Related articles - BL Direct - All 10 versions

Antiangiogenic and immunomodulatory effects of rapamycin on islet endothelium: …


V Cantaluppi, L Biancone, GM Romanazzi … - American Journal of …, 2006 - interscience.wiley.com
Donor intra-islet endothelial cells contribute to neovascularization after transplantation. Several
factors may interfere with this process and ultimately influence islet engraftment. Rapamycin,
a central immunosuppressant in islet transplantation, is an mTOR inhibitor that has been ...
Cited by 27 - Related articles - BL Direct - All 5 versions

In vivo immune modulatory activity of hepatic stellate cells in mice


CH Chen, LM Kuo, Y Chang, W Wu, C Goldbach, … - Hepatology, 2006 - interscience.wiley.com
Accumulating data suggest that hepatic tolerance, initially demonstrated by spontaneous acceptance
of liver allografts in many species, results from an immune regulatory activity occurring in the
liver. However, the responsible cellular and molecular components have not been ...
Cited by 26 - Related articles - BL Direct - All 3 versions


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