- ►jimmunol.org M Rieck, A Arechiga, S Onengut-Gumuscu, C … - The Journal of Immunology, 2007 - Am Assoc Immnol A variant of the PTPN22 gene, 1858C/T, is associated with an increased risk for
the development of a wide array of autoimmune disorders. It is known that the
protein tyrosine phosphatase Lyp encoded by this gene has an inhibitory ... Cited by 47 - Related articles - All 2 versions
- ►pnas.org C Beeton, H Wulff, NE Standifer, P Azam, KM … - Proceedings of the National Academy of Sciences, 2006 - National Acad Sciences Autoreactive memory T lymphocytes are implicated in the pathogenesis of
autoimmune diseases. Here we demonstrate that disease-associated autoreactive T
cells from patients with type-1 diabetes mellitus or rheumatoid arthritis ... Cited by 42 - Related articles - BL Direct - All 11 versions
- ►bloodjournal.org [PDF] I Kim, OH Yilmaz, SJ Morrison - Blood, 2005 - Am Soc Hematology . Hematology; all rights reserved Copyright 2007 by The American Society of DC
20036. by the American Society of Hematology, 1900 M St, NW, Suite 200,
Washington Blood (print ISSN 0006-4971, online ISSN 1528-0020), is ... Cited by 40 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org H Reijonen, R Mallone, AK Heninger, EM … - diabetes, 2004 - Am Diabetes Assoc Negative selection of self-reactive T-cells during thymic development, along
with activation-induced cell death in peripheral lymphocytes, is designed to
limit the expansion and persistence of autoreactive T-cells. Autoreactive T- ... Cited by 37 - Related articles - BL Direct - All 12 versions
- ►daegu.ac.kr [PDF] MA Atkinson - Diabetes, 2005 - Am Diabetes Assoc Thirty years ago, a convergence of investigational ob- servations lead to the
now widely accepted notion that type 1 diabetes results from an autoimmune
destruction of insulin-producing -cells in subjects genetically pre- ... Cited by 28 - Related articles - All 3 versions
- ►shouxi.net MA Atkinson - Diabetes, 2005 - Am Diabetes Assoc Thirty years ago, a convergence of investigational observations lead to the now
widely accepted notion that type 1 diabetes results from an autoimmune
destruction of insulin-producing β-cells in subjects genetically ... Cited by 20 - Related articles - All 9 versions
- ►hematologylibrary.org R Mallone, SA Kochik, H Reijonen, B Carson … - Blood, 2005 - bloodjournal.hematologylibrary.org One of the key determinants of differential outcomes for both autoimmune and
normal T-cell responses is the functional T-cell avidity. The overall T-cell
avidity is determined by a number of components, including the intrinsic ... Cited by 19 - Related articles - BL Direct - All 6 versions
- ►archives-ouvertes.fr [PDF] R Mallone, GT Nepom - American journal of therapeutics, 2005 - journals.lww.com Recognition of a peptide-MHC complex by the T cell receptor (TCR) is a key
interaction that initiates T lymphocyte activation or silencing during an immune
response. Fluorochrome-labeled recombinant MHC class II-peptide reagents ... Cited by 12 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org E Martinuzzi, G Novelli, M Scotto, P Blancou, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—CD8 + T-cell reactivities were less frequent at follow-up, as 28.6% of
responses tested positive at type 1 diabetes diagnosis vs. 13.2% after a median
of 11 months (P = 0.003). While GAD and IA-2 autoantibody (aAb) titers were ... Cited by 12 - Related articles - BL Direct - All 9 versions
GT Nepom - Advances in immunology, 2005 - Elsevier Self-reactivity is an intrinsic property of the human immune system.
Autoreactive T cells derive directly from the developmental requirement for TCR
engagement by self-antigens during lymphocyte maturation. The fundamental ... Cited by 6 - Related articles - BL Direct - All 5 versions
