- ►jimmunol.org J Cantor, K Haskins - The Journal of Immunology, 2005 - Am Assoc Immnol Effector function of T cells in autoimmune diabetes has been widely studied with mixed populations
of lymphoid T cells stimulated ex vivo, but this approach does not permit evaluation of the contribution
by a single T cell clone in the inflammatory site during pathogenesis. We have ... Cited by 23 - Related articles - BL Direct - All 4 versions
K Haskins - Advances in immunology, 2005 - Elsevier T-cell clones that can efficiently transfer diabetes to prediabetic nonobese diabetic (NOD) mice
provide a powerful approach to dissecting the autoimmune disease process and for investigating
immunoregulation. Diabetogenic T-cell clones carried in culture allow for detailed ... Cited by 21 - Related articles - BL Direct - All 4 versions
JM Jasinski, L Yu, M Nakayama, MM Li, MA Lipes, GS … - Diabetes, 2006 - Am Diabetes Assoc A series of recent studies in humans and the NOD mouse model have highlighted the central
role that autoimmunity directed against insulin, in particular the insulin B chain 9-23 peptide,
may play in the pathogenesis of type 1 diabetes. Both pathogenic and protective T-cell ... Cited by 17 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org UC Rogner, F Lepault, MC Gagnerault, D Vallois, J … - Diabetes, 2006 - Am Diabetes Assoc The genetic locus Idd6 confers susceptibility to the spontaneous development of type 1 diabetes
in the NOD mouse. Our studies on disease resistance of the congenic mouse strain NOD.C3H
6.VIII showed that Idd6 influences T-cell activities in the peripheral immune system and ... Cited by 10 - Related articles - BL Direct - All 7 versions
- ►jimmunol.org J Cantor, K Haskins - The Journal of Immunology, 2007 - Am Assoc Immnol Adoptive transfer of diabetogenic CD4 Th1 T cell clones into young NOD or NOD.scid recipients
rapidly induces onset of diabetes and also provides a system for analysis of the pancreatic
infiltrate. Although many reports have suggested a role for macrophages in the ... Cited by 9 - Related articles - All 3 versions
- ►nih.gov [PDF] D Homann, GS Eisenbarth - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Autoimmune diseases such as the diabetes that develops in NOD mice depend on immunologic
recognition of specific autoantigens, but recognition can result in a pathogenic or protective T
cell response. A study by Du et al. in this issue of the JCI demonstrates that TGF-β ... Cited by 9 - Related articles - BL Direct - All 10 versions
- ►jimmunol.org DR Tonkin, J He, G Barbour, K Haskins - The Journal of Immunology, 2008 - Am Assoc Immnol Regulatory T cells (Tregs) can potentially be used as tools to suppress pathogenic T cells in
autoimmune diseases such as type 1 diabetes. For use in therapy it is critically important to determine
whether suppression by Tregs requires a population specific for the target of ... Cited by 6 - Related articles - All 3 versions
AR Burton, E Vincent, PY Arnold, GP Lennon, M … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Neither GAD- nor IA2-specific TCRs mediated T-cell islet infiltration or diabetes even
though T-cells developed in these Rg mice and responded to their cognate epitope. IA2β/phogrin
and insulin-specific Rg T-cells produced variable levels of insulitis, with one TCR ... Cited by 8 - Related articles - BL Direct - All 4 versions
JA GEBE, B FALK, K UNRATH, GT … - ANNALS-NEW YORK …, 2007 - interscience.wiley.com Abstract : Glutamic acid decarboxylase (GAD65) and insulin are implicated as target antigens
in the pathogenesis of human diabetes through correlative measurements of humoral and cellular
reactivity to them in diabetics and at-risk diabetic individuals. Recently, an age-dependent ... Cited by 2 - Related articles - BL Direct - All 6 versions
