- ►rh.dk [PDF] LL Baggio, DJ Drucker - Gastroenterology, 2007 - Elsevier This review focuses on the mechanisms regulating the synthesis, secretion, biological
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic
polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). The published literature was ... Cited by 179 - Related articles - All 25 versions
- ►diabetesjournals.org CF Deacon - Diabetes, 2004 - Am Diabetes Assoc Glucagon-like peptide (GLP)-1 is an incretin hormone with potent glucose-dependent insulinotropic
and glucagonostatic actions, trophic effects on the pancreatic β-cells, and inhibitory effects on
gastrointestinal secretion and motility, which combine to lower plasma glucose and ... Cited by 155 - Related articles - BL Direct - All 5 versions
M Bayes, X Rabasseda, JR Prous - Methods and findings in …, 2006 - journals.prous.com Contributing Editors: P. Cole, C. Orellana, JA Vallès, RM a . Antonijoan, KP Mohana Priya,
M. Priya, V. Renuga, R. Sree Lekha, B. Priya, A. Tomillero, G. Krithiga and E. Banu Rekha. Cited by 148 - Related articles - All 9 versions
T Vilsbøll, M Zdravkovic, T Le-Thi, T Krarup, O … - Diabetes Care, 2007 - Am Diabetes Assoc Main inclusion criteria were patients aged ≥18 years with type 2 diabetes and A1C ≥7.5 and
≤10.0% (diet) or ≥7.0 and ≤9.5% (mono–oral antidiabetes drug); previous therapy was
discontinued. Fasting plasma glucose (FPG) at randomization was 7–13 mmol/l. If FPG ... Cited by 117 - Related articles - BL Direct - All 5 versions
- ►physiology.org JJ Holst - Physiological reviews, 2007 - Am Physiological Soc Glucagon-like peptide 1 (GLP-1) is a 30-amino acid peptide hormone produced in the intestinal
epithelial endocrine L-cells by differential processing of proglucagon, the gene which is expressed
in these cells. The current knowledge regarding regulation of proglucagon gene ... Cited by 119 - Related articles - BL Direct - All 5 versions
- ►endojournals.org BL Wajchenberg - Endocrine reviews, 2007 - Endocrine Soc There is a progressive deterioration in ß-cell function and mass in type 2 diabetics. It was found
that islet function was about 50% of normal at the time of diagnosis, and a reduction in ß-cell
mass of about 60% was shown at necropsy. The reduction of ß-cell mass is attributable to ... Cited by 105 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org NN Zammitt, BM Frier - Diabetes Care, 2005 - Am Diabetes Assoc The importance of strict glycemic control to limit the risk of diabetic vascular complications is
indisputable, but many barriers obstruct its attainment. Hypoglycemia is recognized to be a major
limitation in achieving good control in type 1 diabetes (1) but has been considered to be a ... Cited by 89 - Related articles - All 6 versions
- ►nih.gov DJ Drucker - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig The gastrointestinal tract has a crucial role in the control of energy homeostasis through its role
in the digestion, absorption, and assimilation of ingested nutrients. Furthermore, signals from
the gastrointestinal tract are important regulators of gut motility and satiety, both of which ... Cited by 87 - Related articles - BL Direct - All 11 versions
MC Riddle, DJ Drucker - Diabetes Care, 2006 - Am Diabetes Assoc Current therapies for type 2 diabetes are frequently associated with inadequate control of postprandial
hyperglycemia, weight gain, and, in the case of oral agents, loss of efficacy over time. A better
understanding of physiological responses to meals is leading to the development of new ... Cited by 72 - Related articles - BL Direct - All 10 versions
BE Dunning, JE Foley, B Ahren - Diabetologia, 2005 - Springer Abstract Although there is abundant evidence that hyper- glucagonaemia plays a key role in
the development of hy- perglycaemia in type 2 diabetes, efforts to understand and correct this
abnormality have been overshadowed by the emphasis on insulin secretion and action. ... Cited by 70 - Related articles - BL Direct - All 3 versions
