- ►nih.gov SE Shoelson, J Lee, AB Goldfine - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Over a hundred years ago, high doses of salicylates were shown to lower glucose
levels in diabetic patients. This should have been an important clue to link
inflammation to the pathogenesis of type 2 diabetes (T2D), but the ... Cited by 413 - Related articles - BL Direct - All 11 versions
SA Summers - Progress in Lipid Research, 2006 - Elsevier Obesity predisposes individuals to the development of insulin resistance in
skeletal muscle and the liver, and researchers have recently proposed two
mechanisms by which excess adiposity antagonizes insulin action in ... Cited by 114 - Related articles - All 3 versions
- ►jbc.org S Stratford, KL Hoehn, F Liu, SA Summers - Journal of Biological Chemistry, 2004 - ASBMB The sphingolipid ceramide negatively regulates insulin action by inhibiting
Akt/protein kinase B (PKB), a serine/threonine kinase that is a central
regulator of glucose uptake and anabolic metabolism. Despite considerable ... Cited by 69 - Related articles - BL Direct - All 4 versions
- ►physiology.org CR Bruce, A Thrush, VA Mertz, V Bezaire, A … - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc Muscle fatty acid (FA) metabolism is impaired in obesity and insulin resistance,
reflected by reduced rates of FA oxidation and accumulation of lipids. It has
been suggested that interventions that increase FA oxidation may enhance ... Cited by 68 - Related articles - BL Direct - All 5 versions
- ►physiology.org JS Lee, SK Pinnamaneni, SJ Eo, IH Cho, JH … - Journal of applied physiology, 2006 - Am Physiological Soc Consumption of a Western diet rich in saturated fats is associated with obesity
and insulin resistance. In some insulin-resistant phenotypes this is associated
with accumulation of skeletal muscle fatty acids. We examined the effects ... Cited by 60 - Related articles - BL Direct - All 9 versions
- ►jbc.org JA Chavez, WL Holland, J Bar, K Sandhoff, … - Journal of Biological Chemistry, 2005 - ASBMB Recent studies indicate that insulin resistance and type 2 diabetes result from
the accumulation of lipids in tissues not suited for fat storage, such as
skeletal muscle and the liver. To elucidate the mechanisms linking ... Cited by 55 - Related articles - All 6 versions
- ►diabetesjournals.org SA Summers, DH Nelson - Diabetes, 2005 - Am Diabetes Assoc Metabolic syndrome X and type 2 diabetes share many metabolic and morphological
similarities with Cushing's syndrome, a rare disorder caused by systemic
glucocorticoid excess. Pathologies frequently associated with these ... Cited by 46 - Related articles - All 10 versions
WL Holland, TA Knotts, JA Chavez, LP Wang … - Nutrition reviews, 2007 - ingentaconnect.com Lipid abnormalities such as obesity, increased circu- lating free fatty acid
levels, and excess intramyocel- lular lipid accumulation are frequently
associated with insulin resistance. These observations have prompted ... Cited by 42 - Related articles - BL Direct - All 5 versions
- ►physiology.org A Dobrzyn, P Dobrzyn, SH Lee, M Miyazaki, … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc Stearoyl-CoA desaturase (SCD) has recently been shown to be a critical control
point of lipid partitioning and body weight regulation. Lack of SCD1 function
significantly increases insulin sensitivity in skeletal muscles and ... Cited by 38 - Related articles - All 4 versions
- ►endojournals.org MJ Watt, A Hevener, GI Lancaster, MA … - Endocrinology, 2006 - Endocrine Soc Ciliary neurotrophic factor (CNTF) is a member of the gp130 receptor cytokine
family recently identified as an antiobesity agent in rodents and humans by
mechanisms that remain unclear. We investigated the impact of acute CNTF ... Cited by 36 - Related articles - All 5 versions
