H Kolb, T Mandrup-Poulsen - Diabetologia, 2005 - Springer Abstract Subclinical, low-grade systemic inflammation has been observed in
patients with type 2 diabetes and in those at increased risk of the disease.
This may be more than an epiphenomenon. Alleles of genes encoding immune/ ... Cited by 116 - Related articles - BL Direct - All 5 versions
- ►jbc.org TR Koves, P Li, J An, T Akimoto, D Slentz, … - Journal of Biological Chemistry, 2005 - ASBMB Peroxisome proliferator-activated receptor- co-activator 1 (PGC1 ) is a
promiscuous co-activator that plays a key role in regulating mitochondrial
biogenesis and fuel homeostasis. Emergent evidence links decreased skeletal ... Cited by 104 - Related articles - BL Direct - All 4 versions
JL Leahy - Archives of medical research, 2005 - Elsevier The pathological sequence for type 2 diabetes is complex and entails many
different elements that act in concert to cause that disease. This review
proposes a sequence of events and how they interact by a careful analysis ... Cited by 102 - Related articles - All 14 versions
- ►jbc.org A Carriere, MC Carmona, Y Fernandez, M … - Journal of Biological Chemistry, 2004 - ASBMB Recent reports emphasize the importance of mitochondria in white adipose tissue
biology. In addition to their crucial role in energy homeostasis, mitochondria
are the main site of reactive oxygen species generation. When moderately ... Cited by 78 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org GK Bandyopadhyay, JG Yu, J Ofrecio, JM … - Diabetes, 2006 - Am Diabetes Assoc Increased accumulation of fatty acids and their derivatives can impair
insulin-stimulated glucose disposal by skeletal muscle. To characterize the
nature of the defects in lipid metabolism and to evaluate the effects of ... Cited by 78 - Related articles - BL Direct - All 5 versions
AN Carley, DL Severson - BBA-Molecular and Cell Biology of Lipids, 2005 - Elsevier The metabolic phenotype of hearts has been investigated using rodent models of
type 2 diabetes which exhibit obesity and insulin resistance: db/db and ob/ob
mice, and Zucker fatty and ZDF rats. In general, cardiac fatty acid (FA) ... Cited by 73 - Related articles - All 3 versions
JA Hawley - Diabetes/Metabolism Reviews - interscience.wiley.com During the past half-century, there has been a dramatic increase in the
incidence of obesity, insulin resistance and type 2 diabetes. A hallmark feature
of these conditions is impaired glucose tolerance (IGT). Cross-sectional ... Cited by 62 - Related articles - BL Direct - All 4 versions
- ►endojournals.org A Wiederkehr, CB Wollheim - Endocrinology, 2006 - Endocrine Soc Mitochondria are essential for intermediary metabolism as well as energy
production in the cell. Their aerobic metabolism permits oxidation of glucose
and fatty acids for the generation of ATP and other intermediates that are ... Cited by 53 - Related articles - BL Direct - All 4 versions
- ►shouxi.net M Mogensen, K Sahlin, M Fernström, D … - Diabetes, 2007 - Am Diabetes Assoc We tested the hypothesis of a lower respiratory capacity per mitochondrion in
skeletal muscle of type 2 diabetic patients compared with obese subjects. Muscle
biopsies obtained from 10 obese type 2 diabetic and 8 obese nondiabetic ... Cited by 50 - Related articles - BL Direct - All 6 versions
