- ►ebmonline.org RV Farese, MP Sajan, ML Standaert - Experimental Biology and Medicine, 2005 - SEBM Glucose transport into muscle is the initial process in glucose clearance and is uniformly defective
in insulin-resistant conditions of obesity, metabolic syndrome, and Type II diabetes mellitus. Insulin
regulates glucose transport by activating insulin receptor substrate-1 (IRS-1)–dependent ... Cited by 51 - Related articles - BL Direct - All 3 versions
- ►ahajournals.org HC Chen, RV Farese Jr - Arteriosclerosis, thrombosis, and vascular …, 2005 - Am Heart Assoc Because the ability to make triglycerides is essential for the accumulation of adipose tissue, inhibition
of triglyceride synthesis may ameliorate obesity and its related medical consequences. Acyl coenzyme
A (CoA):diacylglycerol acyltransferase 1 (DGAT1) is 1 of 2 DGAT enzymes that catalyze ... Cited by 44 - Related articles - All 6 versions
- ►nih.gov L Liu, Y Zhang, N Chen, X Shi, B Tsang, … - Journal of Clinical …, 2007 - Am Soc Clin Investig Increased fat deposition in skeletal muscle is associated with insulin resistance. However, exercise
increases both intramyocellular fat stores and insulin sensitivity, a phenomenon referred to as
“the athlete's paradox”. In this study, we provide evidence that augmenting triglyceride ... Cited by 46 - Related articles - BL Direct - All 9 versions
R Farese, M Sajan, M Standaert - Biochemical Society …, 2005 - bst.portlandpress.com It now seems clear that aPKC (atypical protein kinase C) isoforms are required for insulin-stimulated
glucose transport in muscle and adipocytes. Moreover, there are marked defects in the activation
of aPKCs under a variety of insulin-resistant conditions in humans, monkeys and rodents. ... Cited by 34 - Related articles - Cached - All 9 versions
R Suzuki, K Tobe, M Aoyama, K Sakamoto, M … - Journal of Biological …, 2005 - ASBMB Acyl-CoA:diacylglycerol acyltransferase (DGAT) enzymes catalyze the final step in mammalian
triglyceride synthesis, and their functions are considered to be involved in the mechanisms of
obesity, insulin resistance, and leptin resistance. Insulin receptor substrate-2 (IRS-2)- ... Cited by 23 - Related articles - All 13 versions
J Kusunoki, A Kanatani, DE Moller - Endocrine, 2006 - Springer Received October 20, 2005; Accepted October 20, 2005. Author to whom all correspondence
and reprint requests should be addressed: David E. Moller, MD, Lilly Research Laboratories,
Indianapolis, IN 46285. E-mail: mollerda@lilly.com or Jun Kusunoki, PhD, Tsukuba ... Cited by 21 - Related articles - BL Direct - All 3 versions
S Timmers, P Schrauwen, J de Vogel - Physiology & Behavior, 2008 - Elsevier Failure of insulin to elicit an increase in glucose uptake and metabolism in target tissues such
as skeletal muscle is a major characteristic of non-insulin dependent type 2 diabetes
mellitus. A strong correlation between intramyocellular triacylglycerol concentrations and ... Cited by 21 - Related articles - All 2 versions
- ►jlr.org CLE Yen, SJ Stone, S Koliwad, C Harris, RV Farese … - The Journal of Lipid …, 2008 - ASBMB Triacylglycerols (triglycerides) (TGs) are the major storage molecules of metabolic energy and
FAs in most living organisms. Excessive accumulation of TGs, however, is associated with human
diseases, such as obesity, diabetes mellitus, and steatohepatitis. The final and the only ... Cited by 19 - Related articles - All 9 versions
SG Shaw, PJ Boden - Current Vascular Pharmacology, 2005 - ingentaconnect.com Abstract: There is increasing evidence to suggest that chronic activation of the endothelin-1 system
can lead to heterologous desensitization of the glucose-regulatory and mitogenic actions of insulin
with subsequent development of glucose intolerance, hyperinsulinemia, impaired ... Cited by 11 - Related articles - BL Direct - All 2 versions
HC Chen - Nutrition & Metabolism, 2006 - biomedcentral.com Abstract Although the ability to make triglycerides is essential for normal physiology, excess accumulation
of triglycerides results in obesity and is associated with insulin resistance. Inhibition of triglyceride
synthesis, therefore, may represent a feasible strategy for the treatment of obesity and ... Cited by 9 - Related articles - View as HTML - All 12 versions
