PE Cryer - Diabetes, 2005 - Am Diabetes Assoc Iatrogenic hypoglycemia is a problem for people with diabetes. It causes
recurrent morbidity, and sometimes death, as well as a vicious cycle of
recurrent hypoglycemia, precluding maintenance of euglycemia over a ... Cited by 75 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org MA Ravier, GA Rutter - Diabetes, 2005 - Am Diabetes Assoc The mechanisms by which hypoglycemia stimulates glucagon release are still
poorly understood. In particular, the relative importance of direct metabolic
coupling versus paracrine regulation by β-cell secretory products is ... Cited by 66 - Related articles - All 5 versions
B Raju, PE Cryer - Diabetes, 2005 - Am Diabetes Assoc The intraislet insulin hypothesis for the signaling of the glucagon secretory
response to hypoglycemia states that a decrease in arterial glucose → a
decrease in β-cell insulin secretion → a decrease in tonic α-cell ... Cited by 60 - Related articles - All 6 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is
critical for blood glucose homeostasis. It is the major counterpart to insulin
and is released during hypoglycemia to induce hepatic glucose output. The ... Cited by 61 - Related articles - BL Direct - All 4 versions
KM Hope, POT Tran, H Zhou, E Oseid, E … - Diabetes, 2004 - Am Diabetes Assoc The “switch-off” hypothesis to explain β-cell regulation of α-cell
function during hypoglycemia has not been assessed previously in isolated
islets, largely because they characteristically do not respond to glucose ... Cited by 43 - Related articles - BL Direct - All 4 versions
- ►ucla.edu [PDF] JJ MEIER, A BHUSHAN, PC BUTLER - Pediatric research, 2006 - journals.lww.com Both type 1 and type 2 diabetes are characterized by a marked deficit in
beta-cell mass causing insufficient insulin secretion. Beta-cell replacement
strategies may eventually provide a cure for diabetes. Current therapeutic ... Cited by 33 - Related articles - BL Direct - All 7 versions
- ►jbc.org J Diao, Z Asghar, CB Chan, MB Wheeler - Journal of Biological Chemistry, 2005 - ASBMB The insulin receptor (IR) and its signaling appear to be essential for insulin
secretion from pancreatic -cells. However, much less is known about the role of
the IR in -cells. To assess the role of the IR in glucagon and insulin ... Cited by 32 - Related articles - BL Direct - All 6 versions
JJ Meier, LL Kjems, JD Veldhuis, P Lefèbvre, … - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by an ∼60% loss of β-cell mass, a marked
defect in postprandial insulin secretion, and a failure to suppress postprandial
glucagon concentrations. It is possible that postprandial hyperglucagonemia ... Cited by 27 - Related articles - BL Direct - All 9 versions
- ►diabetesjournals.org NR Gosmanov, E Szoke, Z Israelian, T Smith, … - Diabetes Care, 2005 - Am Diabetes Assoc RESULTS—During the 2nd h of the insulin infusion, when somatostatin or saline
was no longer being infused, plasma glucose (∼2.6 mmol/l) and insulin levels
(∼570 pmol/l) were comparable in both sets of experiments (both P > 0.4). ... Cited by 27 - Related articles - All 5 versions
MR Rickels, MH Schutta, R Mueller, JF … - Diabetes, 2005 - Am Diabetes Assoc Islet transplantation can eliminate severe hypoglycemic episodes in patients
with type 1 diabetes; however, whether intrahepatic islets respond appropriately
to hypoglycemia after transplantation has not been fully studied. We ... Cited by 23 - Related articles - BL Direct - All 5 versions
