PE Cryer - Diabetes, 2005 - Am Diabetes Assoc Iatrogenic hypoglycemia is a problem for people with diabetes. It causes
recurrent morbidity, and sometimes death, as well as a vicious cycle of
recurrent hypoglycemia, precluding maintenance of euglycemia over a ... Cited by 72 - Related articles - BL Direct - All 7 versions
B Raju, PE Cryer - Diabetes, 2005 - Am Diabetes Assoc The intraislet insulin hypothesis for the signaling of the glucagon secretory
response to hypoglycemia states that a decrease in arterial glucose → a
decrease in β-cell insulin secretion → a decrease in tonic α-cell ... Cited by 58 - Related articles - All 6 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is
critical for blood glucose homeostasis. It is the major counterpart to insulin
and is released during hypoglycemia to induce hepatic glucose output. The ... Cited by 60 - Related articles - BL Direct - All 4 versions
DJ Drucker - Nature Clinical Practice Endocrinology and Metabolism, 2005 - glucagon.com INTRODUCTION Before the cDNAs and genes encoding pro glucagon were cloned,
pancreatic glucagon was the prin- cipal proglucagon-derived peptide (PGDP) with
well-characterized biologic actions. However, antisera directed against ... Cited by 59 - Related articles - View as HTML - BL Direct - All 6 versions
H Zhou, POT Tran, S Yang, T Zhang, E LeRoy … - Diabetes, 2004 - Am Diabetes Assoc The glucagon response is the first line of defense against hypoglycemia and is
lost in insulin-dependent diabetes. The ß-cell "switch-off" hypothesis proposes
that a sudden cessation of insulin secretion from ß-cells into the portal ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►endojournals.org BE Dunning, JE Gerich - Endocrine reviews, 2007 - Endocrine Soc The hyperglycemic activity of pancreatic extracts was encountered some 80 yr ago
during efforts to optimize methods for the purification of insulin. The
hyperglycemic substance was named "glucagon," and it was subsequently ... Cited by 32 - Related articles - BL Direct - All 5 versions
- ►jbc.org J Diao, Z Asghar, CB Chan, MB Wheeler - Journal of Biological Chemistry, 2005 - ASBMB The insulin receptor (IR) and its signaling appear to be essential for insulin
secretion from pancreatic -cells. However, much less is known about the role of
the IR in -cells. To assess the role of the IR in glucagon and insulin ... Cited by 31 - Related articles - BL Direct - All 6 versions
JJ Meier, LL Kjems, JD Veldhuis, P Lefèbvre, … - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by an ∼60% loss of β-cell mass, a marked
defect in postprandial insulin secretion, and a failure to suppress postprandial
glucagon concentrations. It is possible that postprandial hyperglucagonemia ... Cited by 27 - Related articles - BL Direct - All 9 versions
PE MacDonald, YZ De Marinis, R Ramracheya, … - PLoS Biol, 2007 - biology.plosjournals.org Glucagon, secreted from pancreatic islet α cells, stimulates gluconeogenesis
and liver glycogen breakdown. The mechanism regulating glucagon release is
debated, and variously attributed to neuronal control, paracrine control by ... Cited by 25 - Related articles - Cached - All 7 versions
- ►diabetesjournals.org NR Gosmanov, E Szoke, Z Israelian, T Smith, … - Diabetes Care, 2005 - Am Diabetes Assoc RESULTS—During the 2nd h of the insulin infusion, when somatostatin or saline
was no longer being infused, plasma glucose (∼2.6 mmol/l) and insulin levels
(∼570 pmol/l) were comparable in both sets of experiments (both P > 0.4). ... Cited by 26 - Related articles - All 5 versions
