- ►nih.gov M Prentki, CJ Nolan - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The major focus of this Review is on the mechanisms of islet β cell failure in
the pathogenesis of obesity-associated type 2 diabetes (T2D). As this demise
occurs within the context of β cell compensation for insulin resistance, ... Cited by 196 - Related articles - BL Direct - All 7 versions
- ►shouxi.net MY Donath, JA Ehses, K Maedler, DM … - Diabetes, 2005 - Am Diabetes Assoc A decrease in the number of functional insulin-producing β-cells contributes to
the pathophysiology of type 2 diabetes. Opinions diverge regarding the relative
contribution of a decrease in β-cell mass versus an intrinsic defect in ... Cited by 85 - Related articles - BL Direct - All 6 versions
- ►shouxi.net C Huang, C Lin, L Haataja, T Gurlo, AE Butler … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Endoplasmic reticulum (ER) stress–induced apoptosis may be a
common cause of cell attrition in diseases characterized by misfolding and
oligomerisation of amyloidogenic proteins. The islet in type 2 diabetes is ... Cited by 55 - Related articles - BL Direct - All 5 versions
ST Ferreira, MN Vieira, FG De Felice - IUBMB life, 2007 - interscience.wiley.com It is also possible that your web browser is not configured or not able to
display style sheets. In this case, although the visual presentation will be
degraded, the site should continue to be functional. We recommend using the ... Cited by 42 - Related articles - BL Direct - All 5 versions
- ►cdlib.org [PDF] - Free from Publisher RA Ritzel, AE Butler, RA Rizza, JD Veldhuis, … - Diabetes Care, 2006 - Am Diabetes Assoc In type 2 diabetes there is a progressive defect of insulin secretion that
precedes the development of hyperglycemia (1). This defect appears to be at
least in part due to a deficit in β-cell mass (2–4). Several therapeutic ... Cited by 41 - Related articles - BL Direct - All 9 versions
- ►nih.gov V Luibl, JM Isas, R Kayed, CG Glabe, R … - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Protein misfolding and aggregation are thought to underlie the pathogenesis of
many amyloid diseases, such as Alzheimer and Parkinson diseases, whereby a
stepwise protein misfolding process begins with the conversion of soluble ... Cited by 42 - Related articles - BL Direct - All 11 versions
JD Knight, JA Hebda, AD Miranker - Biochemistry, 2006 - yale.edu Page 1. Conserved and Cooperative Assembly of Membrane-Bound R-Helical
States of Islet Amyloid Polypeptide† Jefferson D. Knight ... Cited by 38 - Related articles - View as HTML - All 6 versions
- ►diabetesjournals.org AV Matveyenko, PC Butler - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by defects in insulin secretion and action and
is preceded by impaired fasting glucose (IFG). The islet anatomy in IFG and type
2 diabetes reveals an ∼50 and 65% deficit in β-cell mass, with increased ... Cited by 39 - Related articles - BL Direct - All 4 versions
- ►endojournals.org D Scheuner, RJ Kaufman - Endocrine Reviews, 2008 - Endocrine Soc The endoplasmic reticulum (ER) is the entry site into the secretory pathway for
newly synthesized proteins destined for the cell surface or released into the
extracellular milieu. The study of protein folding and trafficking within ... Cited by 37 - Related articles - BL Direct - All 5 versions
- ►endojournals.org CY Lin, T Gurlo, L Haataja, WA Hsueh, PC … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Methods and Results: Vehicle or h-IAPP was applied to human islets with or
without RSG (10 and 50 µM) for 48 h. A 2-fold increase in the number of
terminal deoxynucleotidyl transferase-mediated deoxy-UTP nick end labeling- ... Cited by 36 - Related articles - BL Direct - All 4 versions
