- ►diabetesjournals.org FM Matschinsky, MA Magnuson, D Zelent, TL … - Diabetes, 2006 - Am Diabetes Assoc The glucose-phosphorylating enzyme glucokinase has structural, kinetic, and
molecular genetic features that are ideal for its primary role as glucose sensor
in a network of neuro/endocrine sentinel cells that maintain glucose ... Cited by 75 - Related articles - BL Direct - All 10 versions
FM Matschinsky - Current Diabetes Reports, 2005 - Springer Catalytic Function and Structure of GK Glucokinase or hexokinase IV is one of
four glucose-phospho- rylating isoenzymes in mammalian tissues, which has very
distinct structural and catalytic characteristics [1]. A word about ... Cited by 25 - Related articles - BL Direct - All 3 versions
I Barbaric, S Wells, A Russ, TN Dear - Environmental and Molecular Mutagenesis, 2007 - interscience.wiley.com N-ethyl-N-nitrosourea (ENU) mutagenesis in mice has become a standard tool for
(i) increasing the pool of mutants in many areas of biology, (ii) identifying
novel genes involved in physiological processes and disease, and (iii) in ... Cited by 11 - Related articles - BL Direct - All 4 versions
N Neubauer, RN Kulkarni - ILAR JOURNAL, 2006 - dels.nas.edu Type 2 diabetes is a polygenic disease that can lead to severe complications in
multiple tissues. Rodent models have been used widely for investigating the
pathophysiol- ogy underlying type 2 diabetes and for examining the po- ... Cited by 8 - Related articles - View as HTML - BL Direct - All 2 versions
- ►nih.gov PL Oliver, E Bitoun, KE Davies - Mammalian Genome, 2007 - Springer Abstract One of the long-term goals of mutagenesis programs in the mouse has
been to generate mutant lines to facilitate the functional study of every
mammalian gene. With a combination of complementary genetic approaches and ... Cited by 5 - Related articles - BL Direct - All 5 versions
- ►physiology.org B Aigner, B Rathkolb, N Herbach, MH de … - American Journal of Physiology- Endocrinology And …, 2008 - Am Physiological Soc More than 150 million people suffer from diabetes mellitus worldwide, and this
number is expected to rise substantially within the next decades. Despite its
high prevalence, the pathogenesis of diabetes mellitus is not completely ... Cited by 5 - Related articles - BL Direct - All 4 versions
QM Anstee, RD Goldin, M Wright, A Martinelli … - Journal of Thrombosis and Haemostasis, 2008 - interscience.wiley.com Summary. Background: There is strong evidence demonstrating that coagulation
system activation contributes to wound healing and promotes organ fibrosis.
Several epidemiological studies have now shown that prothrombotic status, ... Cited by 4 - Related articles - All 3 versions
- ►diabetesjournals.org M Goldsworthy, A Hugill, H Freeman, E Horner … - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS— Haploinsufficiency of the insulin receptor and
associated mild insulin resistance has been used to sensitize an
N-ethyl-N-nitrosourea (ENU) screen to identify novel mutations resulting in ... Cited by 3 - Related articles - All 6 versions
S Mohan, V Chest, RB Chadwick, JE Wergedal … - Bone, 2007 - Elsevier Phenotype-driven mutagenesis approach in the mouse holds much promise as a
method for revealing gene function. Earlier, we have described an
N-ethyl-N-nitrosourea (ENU) mutagenesis screen to create genome-wide ... Cited by 3 - Related articles - All 23 versions
