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Scholar Results 1 - 10 of about 23 citing Holm: Interaction and association analysis of a type 1 diabetes susceptibility locus on chromosom.... (0.11 sec) 

The diabetes-linked transcription factor PAX4 promotes {beta}-cell proliferation and survival …

- rupress.org
T Brun, I Franklin, L St-Onge, A Biason- … - Journal of Cell Biology, 2004 - jcb.rupress.org
The mechanism by which the ß-cell transcription factor Pax4 influences cell
function/mass was studied in rat and human islets of Langerhans. Pax4
transcripts were detected in adult rat islets, and levels were induced by ...
Cited by 57 - Related articles - All 11 versions

Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta …


A Biason-Lauber, B Boehm, M Lang-Muritano, … - Diabetologia, 2005 - Springer
Page 1. Diabetologia (2005) 48: 900–905 DOI 10.1007/s00125-005-1723-5 ARTICLE A.
Biason-Lauber . B. Boehm . M. Lang-Muritano . BR Gauthier . T. Brun . ...
Cited by 30 - Related articles - All 4 versions

The transcription factor PAX4 acts as a survival gene in INS-1E insulinoma cells


T Brun, DL Duhamel, KHH He, CB Wollheim, … - Oncogene, 2007 - nature.com
The paired/homeodomain transcription factor Pax4 is essential for islet -cell
generation during pancreas development and their survival in adulthood. High
Pax4 expression was reported in human insulinomas indicating that ...
Cited by 12 - Related articles - BL Direct - All 4 versions

Pax4 paired domain mediates direct protein transduction into mammalian cells

- endojournals.org
J Lu, G Li, MS Lan, S Zhang, W Fan, H Wang, … - Endocrinology, 2007 - Endocrine Soc
Pax4, a paired-box transcription factor, is a key regulator of pancreatic islet
cell growth and differentiation. Here, we report for the first time that the
Pax4 protein can permeate into various cell types including pancreatic ...
Cited by 6 - Related articles - BL Direct - All 4 versions

A focus on the role of Pax4 in mature pancreatic islet {beta}-cell expansion and survival in …

- endocrinology-journals.org
T Brun, BR Gauthier - Journal of Molecular Endocrinology, 2008 - Soc Endocrinology
Blood glucose homeostasis is achieved by the regulation of insulin and glucagon
secretion from the pancreatic islet β- and -cells. Diabetes mellitus, which
comprises a heterogeneous group of hyperglycaemic disorders, results mainly ...
Cited by 5 - Related articles - All 4 versions

Lack of association of PAX4 gene with type 1 diabetes in the Finnish and Hungarian …

- shouxi.net
R Hermann, J Mantere, K Lipponen, R Veijola, … - Diabetes, 2005 - Am Diabetes Assoc
We aimed to assess the possible contribution of the PAX4 transcription factor
gene to the genetic background of type 1 diabetes. We analyzed four coding
polymorphisms of the PAX4 gene in 498 cases with type 1 diabetes and 825 ...
Cited by 5 - Related articles - BL Direct - All 6 versions

The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and …

- oxfordjournals.org
T Brun, KHH He, R Lupi, B Boehm, A … - Human Molecular Genetics, 2008 - Oxford Univ Press
We previously demonstrated that the transcription factor Pax4 is important for
β-cell replication and survival in rat islets. Herein, we investigate Pax4
expression in islets of non-diabetic and diabetic donors, its regulation by ...
Cited by 4 - Related articles - BL Direct - All 4 versions

MAPK Kinase Kinase-1 Is Essential for Cytokine-Induced c-Jun NH2-Terminal Kinase and …

- diabetesjournals.org
D Mokhtari, JW Myers, N Welsh - Diabetes, 2008 - Am Diabetes Assoc
RESULTS—We observed that overexpression of wild-type MEKK-1, but not of a
kinase dead MEKK-1 mutant, resulted in potentiation of cytokine-induced JNK
activation, inhibitor of B (I B) degradation, and cell death. ...
Cited by 2 - Related articles - All 4 versions

Short Report No evidence of association of the PDCD1 gene with Type 1 diabetes


S Fawwaz, P Nikamo, C Törn, M Landin- … - Diabet. Med, 2007 - interscience.wiley.com
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Related articles - BL Direct - All 2 versions

The Diabetes-Linked Transcription Factor Pax4 is Expressed in Human Pancreatic Islets …


N Sauter, M Donath, P Marchetti, K Maedler, … - Human Molecular Genetics - Oxford Univ Press
1 Department of Cell Physiology and Metabolism, University Medical Center, 1211
Geneva 4, Switzerland; 2 Department of Endocrinology and Metabolism, Metabolic
Unit, University of Pisa, Pisa, Italy; 3 Division of Endocrinology and ...
Related articles - All 2 versions


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