A Denley, LJ Cosgrove, GW Booker, JC Wallace, … - Cytokine and Growth …, 2005 - Elsevier The insulin-like growth factor (IGF) system is a complex network of two soluble ligands; several
cell surface transmembrane receptors and six soluble high-affinity binding-proteins. The IGF
system is essential for normal embryonic and postnatal growth, and plays an important ... Cited by 82 - Related articles - All 13 versions
P De Meyts - Bioessays, 2004 - interscience.wiley.com I present here a personal perspective on more than three decades of research into the structural
biology of the insulin-receptor interaction. The solution of the three-dimensional structure of insulin
in 1969 provided a detailed understanding of the insulin surfaces involved in ... Cited by 56 - Related articles - All 3 versions
- ►cell.com CW Ward, MC Lawrence, VA Streltsov, TE Adams, … - Trends in Biochemical …, 2007 - Elsevier The insulin receptor (IR) and epidermal growth factor receptor (EGFR; also known as ErbB) families
exhibit similarities in the composition of their ectodomains. The past five years have seen structures
determined for all members of the EGFR family including some complexes with ligand or ... Cited by 34 - Related articles - All 6 versions
K Huang, B Xu, SQ Hu, YC Chu, Q Hua, Y Qu, B Li, … - Journal of molecular …, 2004 - Elsevier Binding of insulin to the insulin receptor plays a central role in the hormonal control of
metabolism. Here, we investigate possible contact sites between the receptor and the conserved
non-polar surface of the B-chain. Evidence is presented that two contiguous sites in an α- ... Cited by 35 - Related articles - All 3 versions
- ►endojournals.org A Denley, CC Wang, KA McNeil, MJE … - Molecular …, 2005 - Endocrine Soc We have previously described the phenotype resulting from a missense mutation in the IGF-I
gene, which leads to expression of IGF-I with a methionine instead of a valine at position 44
(Val 44 Met IGF-I). This mutation caused severe growth and mental retardation as well as ... Cited by 25 - Related articles - All 4 versions
C Ward, M Lawrence, V Streltsov, T Garrett, N … - Acta …, 2008 - assets0.pubget.com Abstract The current model for insulin binding to the insulin receptor proposes that there are
two binding sites, referred to as sites 1 and 2, on each monomer in the receptor homodimer and
two binding surfaces on insulin, one involving residues predominantly from the ... Cited by 11 - Related articles - View as HTML - BL Direct - All 4 versions
- ►jbc.org Q Hua, SH Nakagawa, W Jia, K Huang, NB Phillips, … - Journal of Biological …, 2008 - ASBMB Single-chain insulin (SCI) analogs provide insight into the inter-relation of hormone
structure, function, and dynamics. Although compatible with wild-type structure, short connecting
segments (<3 residues) prevent induced fit upon receptor binding and so are essentially ... Cited by 7 - Related articles - All 6 versions
MR Brown, KD Clark, M Gulia, Z Zhao, SF … - Proceedings of the …, 2008 - National Acad Sciences Ingestion of vertebrate blood is essential for egg maturation and transmission of disease-causing
parasites by female mosquitoes. Prior studies with the yellow fever mosquito, Aedes aegypti,
indicated blood feeding stimulates egg production by triggering the release of hormones ... Cited by 7 - Related articles - BL Direct - All 12 versions
- ►jbc.org K Huang, SJ Chan, Q Hua, YC Chu, R Wang, B … - Journal of Biological …, 2007 - ASBMB The contribution of the insulin A-chain to receptor binding is investigated by photo-cross-linking
and nonstandard mutagenesis. Studies focus on the role of Val A3 , which projects within a crevice
between the A- and B-chains. Engineered receptor -subunits containing specific protease ... Cited by 4 - Related articles - All 6 versions
- ►endojournals.org [PDF] A Denley, CC Wang, KA McNeil, MJE … - Molecular …, 2004 - Endocrine Soc Page 1. 1 Structural and functional characteristics of the Val44Met IGF-I missense
mutation: correlation with effects on growth and development Adam Denley*,
Chunxiao C. Wang ¶, Kerrie A. McNeil*, Marie JE Walenkamp**, ... Cited by 4 - Related articles
