- ►cell.com YI Kitamura, T Kitamura, JP Kruse, JC Raum, R … - Cell metabolism, 2005 - Elsevier Diabetes causes pancreatic β cell failure through hyperglycemia-induced
oxidative stress, or “glucose toxicity.” We show that the forkhead protein
FoxO1 protects β cells against oxidative stress by forming a complex with ... Cited by 104 - Related articles - All 14 versions
- ►tufts.edu [PDF] LL Baggio, DJ Drucker, 2006 - Annual Reviews Type 2 diabetes is characterized by hyperglycemia resulting from insulin
resistance in the setting of inadequate β-cell compensation. Currently
available therapeutic agents lower blood glucose through multiple ... Cited by 77 - Related articles - BL Direct - All 10 versions
- ►nih.gov M Matsumoto, S Han, T Kitamura, D Accili - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Hepatic insulin resistance affects both carbohydrate and lipid metabolism. It
has been proposed that insulin controls these 2 metabolic branches through
distinct signaling pathways. FoxO transcription factors are considered ... Cited by 61 - Related articles - BL Direct - All 10 versions
- ►nih.gov H Okamoto, D Accili - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Diabetes is associated with defective β cell function and altered β cell mass.
The mechanisms regulating β cell mass and its adaptation to insulin resistance
are unknown. It is unclear whether compensatory β cell hyperplasia is ... Cited by 53 - Related articles - BL Direct - All 12 versions
- ►jbc.org SJ Kim, K Winter, C Nian, M Tsuneoka, Y … - Journal of Biological Chemistry, 2005 - ASBMB The hormone glucose-dependent insulinotropic polypeptide (GIP) potently
stimulates insulin secretion and promotes -cell proliferation and cell survival.
In the present study we identified Forkhead (Foxo1)-mediated suppression of ... Cited by 47 - Related articles - All 5 versions
- ►shouxi.net QF Collins, Y Xiong, EG Lupo, HY Liu, W Cao - Journal of Biological Chemistry, 2006 - ASBMB Free fatty acids (FFA) are considered as a causative link between obesity and
diabetes. In various animal models and in humans FFA can stimulate hepatic
gluconeogenesis. Although the in vivo role of FFA in hepatic ... Cited by 38 - Related articles - All 6 versions
- ►jbc.org W Cao, QF Collins, TC Becker, J Robidoux, EG … - Journal of Biological Chemistry, 2005 - ASBMB Hepatic gluconeogenesis is essential for maintaining blood glucose levels during
fasting and is the major contributor to postprandial and fasting hyperglycemia
in diabetes. Gluconeogenesis is a classic cAMP/protein kinase A-dependent ... Cited by 39 - Related articles - BL Direct - All 5 versions
- ►shouxi.net V Marchetti, R Menghini, S Rizza, A Vivanti, … - Diabetes, 2006 - Am Diabetes Assoc Dysfunction of mature endothelial cells is thought to play a major role in both
micro- and macrovascular complications of diabetes. However, recent advances in
biology of endothelial progenitor cells (EPCs) have highlighted their ... Cited by 40 - Related articles - BL Direct - All 5 versions
- ►nih.gov X Dong, S Park, X Lin, K Copps, X Yi, MF … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Insulin receptor substrates, including Irs1 and Irs2, integrate insulin and IGF
receptor signals with heterologous pathways to coordinate growth and metabolism.
Since Irs2 is thought to be especially important in hepatic nutrient ... Cited by 36 - Related articles - BL Direct - All 12 versions
